Entry Detail

General Information

Database ID: LDA0002011
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00473
Full Name:long intergenic non-protein coding RNA 473
Category:LncRNA
Species:Homo sapiens
Synonyms:C6orf176|LNC473|bA142J11.1
Chromosome:6
Strand:-
Coordinate:
Start Site(bp):165924048End Site(bp):165988039
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:90632.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Glioma  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Molecular Epidemiology  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3910D000077192
Disease Name:lung adenocarcinomaAdenocarcinoma of Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung non-small cell carcinoma that derives_from epithelial cells of glandular origin.A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.
Alias:bronchogenic lung adenocarcinoma//nonsmall cell adenocarcinomaAdenocarcinoma of Lung//Lung Adenocarcinomas//Lung Adenocarcinoma//Adenocarcinoma, Lung//Adenocarcinomas, Lung

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:386
Network:
Top Causal ncRNAs:
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
LINC00665  (Score: 1)
LINC00511  (Score: 1)
FAM83A-AS1  (Score: 1)
CCAT1  (Score: 0.999893)
H19  (Score: 0.999893)
SNHG17  (Score: 0.999893)
LINC00467  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32351100
Disease Name:Adenocarcinoma of Lung
Sample:lung adenocarcinoma tissues and cells
Dysfunction Pattern:regulation[miR-1294/ROBO1 axis]
Validated Method:CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:The results showed that LINC00473 was up-regulated and miR-1294 was down-regulated in lung adenocarcinoma tissues and cells.In conclusion, LINC00473 acts as a tumor promoter in lung adenocarcinoma by regulating the miR-1294/ROBO1 axis.
Causality:Yes
Causal Description: Functionally, LINC00473 promoted cell proliferation and motility in lung adenocarcinoma by downregulating miR-1294.
Clinical-realted Application: