Entry Detail

General Information

Database ID: LDA0002026
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01503
Full Name:long intergenic non-protein coding RNA 1503
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):129336923End Site(bp):129347477
External Links:
Ensembl ID:ENSG00000233901
Ensembl Transcript ID:N/A
Entrez Gene:100506119.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
gastric cardia adenocarcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6271
Disease Name:gastric cardia adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:
Alias:adenocarcinoma of Cardia of stomach

 

Disease Association Statistics

Total Associated ncRNA Number:8   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
LINC01503  (Score: 0.731059)
SEMA3B  (Score: 0.731059)
SEMA3B-AS1  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:33200343
Disease Name:gastric cardia adenocarcinoma
Sample:GCA tissues and cell lines
Dysfunction Pattern:regulation[miR-133a-5p/VIM Axis and EMT Process]
Validated Method:qRT-PCR//Luciferase Report Assay//RIP
Description:The expression level of LINC01503 was significantly elevated in GCA tissues and cell lines. LINC01503 serves as an oncogenic lncRNA to promote GCA progression via affecting LINC01503/miR-133a-5p/VIM axis and EMT process.
Causality:Yes
Causal Description:Knockdown of LINC01503 significantly reduced proliferation, migration, and invasion ability in GC cells.
Clinical-realted Application:High expression of LINC01503 was correlated with lymph node metastasis, TNM stage, and poor prognosis of GCA patients.