Entry Detail

General Information

Database ID: LDA0002038
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01606
Full Name:long intergenic non-protein coding RNA 1606
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):57218276End Site(bp):57232954
External Links:
Ensembl ID:ENSG00000282395
Ensembl Transcript ID:N/A
Entrez Gene:100507651.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colonic Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:219D003110
Disease Name:colon cancerColonic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the colon.Tumors or cancer of the COLON.
Alias:Colonic Neoplasms//Colonic Neoplasm//Neoplasm, Colonic//Neoplasms, Colonic//Colon Neoplasms//Colon Neoplasm//Neoplasm, Colon//Neoplasms, Colon//Cancer of Colon//Colon Cancers//Colon Cancer//Cancer, Colon//Cancers, Colon//Cancer of the Colon//Colonic Cancer//Cancer, Colonic//Cancers, Colonic//Colonic Cancers//Colon Adenocarcinoma//Adenocarcinoma, Colon//Adenocarcinomas, Colon//Colon Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:272   
More Information
Causal ncRNA Number:210
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
HOTAIR  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
circPPP1R12A  (Score: 0.985791)
CASC9  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RIP//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35485210
Disease Name:Colonic Neoplasms
Sample:colon cancer cell and tissues
Dysfunction Pattern:Interaction( SCD1-Wnt/β-catenin-TFE3 feedback loop signalling)
Validated Method:qRT-PCR//RIP//Transwell Assay
Description:The expression of lncRNA LINC01606 was frequently upregulated in human colon cancer and strongly associated with a poor prognosis. Mechanistically, LINC01606 enhanced the expression of stearoyl-CoA desaturase 1 (SCD1), serving as a competing endogenous RNA to modulate miR-423-5p expression, subsequently activating the canonical Wnt/β-catenin signaling, and transcription factor binding to IGHM enhancer 3 (TFE3) increased LINC01606 transcription after recruitment to the promoter regions of LINC01606.
Causality:Yes
Causal Description:LINC01606 functioned as an oncogene and promotes colon cancer cell growth, invasion and stemness both in vitro and in vivo. Moreover, LINC01606 protected colon cancer cells from ferroptosis by decreasing the concentration of iron, lipid reactive oxygen species, mitochondrial superoxide and increasing mitochondrial membrane potential.
Clinical-realted Application:The expression of lncRNA LINC01606 was frequently upregulated in human colon cancer and strongly associated with a poor prognosis.