Entry Detail

General Information

Database ID: LDA0002054
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01546
Full Name:long intergenic non-protein coding RNA 1546
Category:LncRNA
Species:Homo sapiens
Synonyms:CXorf28|VAL
Chromosome:X
Strand:+
Coordinate:
Start Site(bp):3271820End Site(bp):3284653
External Links:
Ensembl ID:ENSG00000228459
Ensembl Transcript ID:N/A
Entrez Gene:100129464.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Co-IP//CCK8//RIP//qRT-PCR//FISH//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36229913
Disease Name:Stomach Neoplasms
Sample:GCs
Dysfunction Pattern:Interaction(PKM2 )
Validated Method:RNA Pull-Down//Co-IP//CCK8//qRT-PCR//RIP//FISH//Transwell Assay
Description: Long non-coding RNA (lncRNA) VAL is significantly upregulated in GCs and indicates poor prognosis. Mechanistically, VAL strengthens the enzymatic activity of PKM2 and aerobic glycolysis of GC cells through directly binding with PKM2 to abrogate the PKM2-Parkin interaction, and to suppress Parkin-induced polyubiquitination of PKM2.
Causality:Yes
Causal Description:Functional assays showed that VAL promotes GC malignant progression.
Clinical-realted Application:Long non-coding RNA (lncRNA) VAL is significantly upregulated in GCs and indicates poor prognosis.