Entry Detail

General Information

Database ID: LDA0002155
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01638
Full Name:long intergenic non-protein coding RNA 1638
Category:LncRNA
Species:Homo sapiens
Synonyms:lncRNA4114
Chromosome:22
Strand:-
Coordinate:
Start Site(bp):27221350End Site(bp):27224679
External Links:
Ensembl ID:ENSG00000233521
Ensembl Transcript ID:N/A
Entrez Gene:105372978.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
laryngeal squamous cell carcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic ductal adenocarcinoma  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
laryngeal squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2876
Disease Name:laryngeal squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A laryngeal carcinoma that has_material_basis_in squamous cells.
Alias:Epidermoid carcinoma of the Larynx//squamous cell carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
hsa_circ_0067934  (Score: 0.731059)
TACR3-AS1  (Score: 0.731059)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33714208
Disease Name:laryngeal squamous cell carcinoma
Sample:LSCC tissues
Dysfunction Pattern:Interaction(miR-523-5p/BATF3 axis)
Validated Method:In Vivo Experiment//Transfection//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//Transwell Assay
Description:In the present study, we found that LINC01638 was highly expressed in LSCC tissues. In terms of mechanism, LINC01638 was found to sponge miR-523-5p and promote BATF3 expression. In summary, our results demonstrated that LINC01638/miR-523-5p/BATF3 axis plays a crucial function in initiating LSCC development and may be a potential target for tumor therapy.
Causality:Yes
Causal Description: Results from CCK8, colony formation, and transwell assays showed that LINC01638 knockdown suppressed the proliferation, migration and invasion of LSCC cells in vitro. Animal experiments indicated that LINC01638 silencing attenuated tumor growth in vivo.
Clinical-realted Application:And LINC01638 expression was positively correlated with clinical stage and lymph node metastasis. Patients with LINC01638 high expression displayed a low survival rate.