Entry Detail

General Information

Database ID: LDA0002189
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01004
Full Name:long intergenic non-protein coding RNA 1004
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):104981747End Site(bp):104991165
External Links:
Ensembl ID:ENSG00000228393
Ensembl Transcript ID:N/A
Entrez Gene:100216546.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Pituitary Neoplasms  (Score: 0.731059)
Pituitary Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3829D010911
Disease Name:pituitary adenomaPituitary Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pituitary gland benign neoplasm that derives_from glandular epithelial cells.Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Alias:adenoma of the Pituitary glandPituitary Neoplasms//Neoplasm, Pituitary//Neoplasms, Pituitary//Pituitary Neoplasm//Pituitary Tumors//Pituitary Tumor//Tumor, Pituitary//Tumors, Pituitary//Pituitary Adenoma//Adenoma, Pituitary//Adenomas, Pituitary//Pituitary Adenomas//Pituitary Carcinoma//Carcinoma, Pituitary//Carcinomas, Pituitary//Pituitary Carcinomas//Cancer of the Pituitary//Pituitary Cancer//Cancer, Pituitary//Cancers, Pituitary//Cancer of Pituitary//Pituitary Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:336   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01004  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
CASC11  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
RPSAP52  (Score: 0.731059)
circVPS13C  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Transfection//Colony Formation Assay//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//IHC
Weak Evidence:

 

Reference

[1] PubMed ID:35490653
Disease Name:Pituitary Neoplasms
Sample:PA cells
Dysfunction Pattern:Interaction(miR-323a-3p/136-5p/RCN2 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//IHC//Transfection//CCK8//qRT-PCR//Flow Cytometry//FISH//Luciferase Report Assay//Colony Formation Assay
Description: In this study, we discovered that long intergenic non-protein coding RNA 1004 (LINC01004) was aberrantly up-regulated in PA cells. By using bioinformatics tools and a series of mechanism assays, LINC01004 was identified to sponge miR-323a-3p/miR-136-5p to enhance the expression of RCN2 in PA.
Causality:Yes
Causal Description:Functional assays manifested that LINC01004 promoted malignant behaviors of PA cells in vitro and growth of PA in vivo.
Clinical-realted Application: