Entry Detail

General Information

Database ID: LDA0002206
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01048
Full Name:long intergenic non-protein coding RNA 1048
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):37481464End Site(bp):37484784
External Links:
Ensembl ID:ENSG00000230390
Ensembl Transcript ID:N/A
Entrez Gene:103695431.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Skin Neoplasms  (Score: 0.731059)
Skin Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4159D012878
Disease Name:skin cancerSkin Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells.Tumors or cancer of the SKIN.
Alias:CA - skin cancer//malignant neoplasm of skin//melanoma and Non-melanoma skin cancerSkin Neoplasms//Neoplasms, Skin//Neoplasm, Skin//Skin Neoplasm//Cancer of Skin//Skin Cancers//Cancer of the Skin//Skin Cancer//Cancer, Skin//Cancers, Skin

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:48
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.985791)
HOTAIR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
PICSAR  (Score: 0.985791)
circSEC24A  (Score: 0.731059)
circLARP1B  (Score: 0.731059)
PRECSIT  (Score: 0.731059)
SCARNA2  (Score: 0.731059)
H19  (Score: 0.731059)
EZR‑AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:30931936
Disease Name:Skin Neoplasms
Sample:CSCC tissues
Dysfunction Pattern:Interaction[binding to TAF15 ]
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//FISH//RIP//Luciferase Report Assay//EdU Staining//ChIP
Description: Obviously, LINC01048 was expressed higher in the CSCC tissues and recurrence tissues compared with that in adjacent normal tissues and non-recurrence tissues.In conclusion, USF1-induced upregulation of LINC01048 promoted CSCC by interacting with TAF15 to upregulate YAP1.
Causality:Yes
Causal Description:Subsequently, functional assays were conducted to prove the inhibitory effect of silenced LINC01048 on the proliferation and apoptosis of CSCC cells.
Clinical-realted Application:Furthermore, Kaplan-Meier analysis revealed the negative correlation between LINC01048 expression and the overall survival and disease-free survival of CSCC patients.