Entry Detail

General Information

Database ID: LDA0002226
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00974
Full Name:long intergenic non-protein coding RNA 974
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):41549606End Site(bp):41554495
External Links:
Ensembl ID:ENSG00000226629
Ensembl Transcript ID:N/A
Entrez Gene:147093.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Oral Submucous Fibrosis  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Oral Submucous Fibrosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5773D009914
Disease Name:oral submucous fibrosisOral Submucous Fibrosis
Category:Disease OntologyMeSH
Type:Stomatognathic Diseases
Define:A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
Alias:Oral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongueOral Submucous Fibrosis//Fibroses, Oral Submucous//Fibrosis, Oral Submucous//Oral Submucous Fibroses//Submucous Fibroses, Oral//Submucous Fibrosis, Oral

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
LINC00974  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
LINC00974  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Wound Healing Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30447113
Disease Name:Oral Submucous Fibrosis
Sample:OSF tissues
Dysfunction Pattern:Regulation[TGF-β/Smad signaling]
Validated Method:qRT-PCR//Wound Healing Assay
Description:We found that the expression of LINC00974 in OSF tissues or myofibroblasts was aberrantly upregulated, and there was a positive correlation between LINC00974 and myofibroblast markers. Altogether, these findings suggested that arecoline-increased myofibroblast transdifferentiation was via LINC00974-mediated activation of TGF-β signaling.
Causality:Yes
Causal Description:Our results showed that inhibition of LINC00974 suppressed the myofibroblast activities, while overexpression of LINC00974 increased the activation.
Clinical-realted Application: