Entry Detail

General Information

Database ID: LDA0002229
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00958
Full Name:long intergenic non-protein coding RNA 958
Category:LncRNA
Species:Homo sapiens
Synonyms:BLACAT2
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):12979534End Site(bp):12989548
External Links:
Ensembl ID:ENSG00000251381
Ensembl Transcript ID:N/A
Entrez Gene:100506305.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5520D000077195
Disease Name:head and neck squamous cell carcinomaSquamous Cell Carcinoma of Head and Neck
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
Alias:carcinoma of the head and neck//squamous cell carcinoma of the head and neck//squamous cell carcinomas of head and neckSquamous Cell Carcinoma of Head and Neck//Head And Neck Squamous Cell Carcinomas//Squamous Cell Carcinoma, Head And Neck//Squamous Cell Carcinoma of the Head and Neck//Head and Neck Squamous Cell Carcinoma//HNSCC//Carcinoma, Squamous Cell of Head and Neck//Squamous Cell Carcinoma of the Larynx//Laryngeal Squamous Cell Carcinoma//Squamous Cell Carcinoma of Larynx//Squamous Cell Carcinoma of the Nasal Cavity//Oral Tongue Squamous Cell Carcinoma//Hypopharyngeal Squamous Cell Carcinoma//Oral Squamous Cell Carcinoma//Oral Cavity Squamous Cell Carcinoma//Oral Squamous Cell Carcinomas//Squamous Cell Carcinoma of the Mouth//Oropharyngeal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:632   
More Information
Causal ncRNA Number:464
Network:
Top Causal ncRNAs:
XIST  (Score: 1)
CYTOR  (Score: 1)
hsa_circ_0001971  (Score: 1)
MALAT1  (Score: 1)
GAS5  (Score: 1)
HOXA11-AS  (Score: 1)
NORAD  (Score: 1)
MEG3  (Score: 1)
NEAT1  (Score: 1)
CYTOR  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31442551
Disease Name:Squamous Cell Carcinoma of Head and Neck
Sample:OSCC tissue and cell lines
Dysfunction Pattern:Regulation[LINC00958/miR-185-5p/YWHAZ regulatory axis]
Validated Method:CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Description: LINC00958 expression was remarkably up-regulated in the OSCC tissue and cell lines.Taken together, the findings in this research reveal the modulation of LINC00958 for the OSCC tumorigenesis through the miR-185-5p/YWHAZ axis, which might be useful for the mechanical investigation associated with OSCC therapeutic target.
Causality:Yes
Causal Description:Loss- and gain-of-function assays indicated that LINC00958 promoted the proliferation, invasion and reduced the apoptosis of OSCC cells in vitro. In vivo, knockdown of LINC00958 repressed the tumor growth.
Clinical-realted Application:Clinical investigation showed that LINC00958 overexpression was associated with poor prognosis, acting as an independent prognostic factor for OSCC.

[2] PubMed ID:34384029
Disease Name:Squamous Cell Carcinoma of Head and Neck
Sample:OSCC cells
Dysfunction Pattern:Interaction( miR-4306/AIM2/SIRT/p53 )
Validated Method:CCK8//qRT-PCR//RIP
Description:We found that LINC00958 showed upregulation in OSCC cells compared to normal oral epithelial cells.
Causality:Yes
Causal Description: LINC00958 silencing significantly suppressed OSCC cell proliferation, induced cell death and reduced autophagy.
Clinical-realted Application: