Entry Detail

General Information

Database ID: LDA0002233
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC00958
Full Name:long intergenic non-protein coding RNA 958
Category:LncRNA
Species:Homo sapiens
Synonyms:BLACAT2
Chromosome:11
Strand:-
Coordinate:
Start Site(bp):12979534End Site(bp):12989548
External Links:
Ensembl ID:ENSG00000251381
Ensembl Transcript ID:N/A
Entrez Gene:100506305.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:24
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Adenocarcinoma of Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33885186
Disease Name:Endometrial Neoplasms
Sample:EC tissues
Dysfunction Pattern:Interaction(miR-145-3p/TCF4 axis)
Validated Method:In Vivo Experiment//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description:LINC00958 was remarkably upmodulated in EC. LINC00958 was validated to decoy miR-145-3p and repressed its expression, and TCF4 was uncovered to be a target gene of miR-145-3p and negatively modulated by miR-145-3p.
Causality:Yes
Causal Description:Functional experiments confirmed that in vitro knockdown of LINC00958 suppressed EC cell proliferation and metastasis.
Clinical-realted Application:Moreover, its overexpression was strongly linked to unfavorable overall survival of the patients.