Entry Detail

General Information

Database ID: LDA0002282
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01139
Full Name:long intergenic non-protein coding RNA 1139
Category:LncRNA
Species:Homo sapiens
Synonyms:LINK-A|LINKA
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):238480384End Site(bp):238486017
External Links:
Ensembl ID:ENSG00000215808
Ensembl Transcript ID:N/A
Entrez Gene:339535.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic adenocarcinoma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Diabetic Nephropathies  (Score: 0.731059)
Lymphoma, Mantle-Cell  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//ELISA//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32104251
Disease Name:pancreatic adenocarcinoma
Sample:blood
Dysfunction Pattern:Interaction[ROCK1 ]
Validated Method:Western Blot//CCK8//qRT-PCR//ELISA//Transwell Assay
Description:In the present study, it was determined that the plasma levels of LINK-A lncRNA and Rho-associated protein kinase 1 (ROCK1) were significantly increased in patients with pancreatic adenocarcinoma compared with those in healthy controls. Overexpression of LINK-A lncRNA led to upregulation of ROCK1 expression, while overexpression of ROCK1 had no significant effect on LINK-A lncRNA expression. It may therefore be concluded that LINK-A lncRNA may have a role in pancreatic adenocarcinoma, at least in part, by promoting ROCK1 expression.
Causality:Yes
Causal Description: Silencing of LINK-A led to inhibition of pancreatic adenocarcinoma cell proliferation, migration and invasion. Simultaneous overexpression of ROCK1 attenuated the inhibitory effect of LINK-A silencing on cancer cell proliferation, migration and invasion.
Clinical-realted Application: