Entry Detail

General Information

Database ID: LDA0002303
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01139
Full Name:long intergenic non-protein coding RNA 1139
Category:LncRNA
Species:Homo sapiens
Synonyms:LINK-A|LINKA
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):238480384End Site(bp):238486017
External Links:
Ensembl ID:ENSG00000215808
Ensembl Transcript ID:N/A
Entrez Gene:339535.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic adenocarcinoma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Diabetic Nephropathies  (Score: 0.731059)
Lymphoma, Mantle-Cell  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30912527
Disease Name:Ovarian Neoplasms
Sample:ovarian tissues
Dysfunction Pattern:Interaction[HIF1α]
Validated Method:qRT-PCR
Description:As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). In addition, LINK-A overexpression also significantly promoted migration (p<0.05, Figure 4B) and invasion (p<0.05, Figure 4C) of cancer cells. We found that LINK-A was significantly higher in ovarian carcinoma patients than in healthy controls in ovarian biopsies and in serum. LINK-A expression effectively distinguished patients with metastatic ovarian carcinoma from healthy controls. LINK-A overexpression promoted cancer cell migration and invasion, and also Expression[Expression[up-expression]-expression]regulated the expression of HIF1alpha.
Causality:Yes
Causal Description:As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). In addition, LINK-A overexpression also significantly promoted migration (p<0.05, Figure 4B) and invasion (p<0.05, Figure 4C) of cancer cells.
Clinical-realted Application: As shown in Figure 1, compared with the control groExpression[Expression[up-expression]-expression], LINK-A was significantly higher in patients with the 3 types of metastatic ovarian carcinoma (p<0.05), while no significant difference in LINK-A expression was found between non-metastatic ovarian carcinoma and healthy controls (p>0.05). These data suggest that Expression[Expression[up-expression]-expression]regulation of LINK-A in ovarian tissues participates in the distant metastasis of ovarian carcinoma.