Entry Detail

General Information

Database ID: LDA0002304
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01139
Full Name:long intergenic non-protein coding RNA 1139
Category:LncRNA
Species:Homo sapiens
Synonyms:LINK-A|LINKA
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):238480384End Site(bp):238486017
External Links:
Ensembl ID:ENSG00000215808
Ensembl Transcript ID:N/A
Entrez Gene:339535.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Osteosarcoma  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.731059)
pancreatic adenocarcinoma  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Diabetic Nephropathies  (Score: 0.731059)
Lymphoma, Mantle-Cell  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003928
Disease Name:Diabetic Nephropathies
Category:MeSH
Type:Urogenital Diseases
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Alias:Diabetic Nephropathies//Nephropathies, Diabetic//Nephropathy, Diabetic//Diabetic Nephropathy//Diabetic Kidney Disease//Diabetic Kidney Diseases//Kidney Disease, Diabetic//Kidney Diseases, Diabetic//Diabetic Glomerulosclerosis//Glomerulosclerosis, Diabetic//Intracapillary Glomerulosclerosis//Nodular Glomerulosclerosis//Glomerulosclerosis, Nodular//Kimmelstiel-Wilson Syndrome//Kimmelstiel Wilson Syndrome//Syndrome, Kimmelstiel-Wilson//Kimmelstiel-Wilson Disease//Kimmelstiel Wilson Disease

 

Disease Association Statistics

Total Associated ncRNA Number:72   
More Information
Causal ncRNA Number:58
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999998)
MALAT1  (Score: 0.999998)
MIAT  (Score: 0.985791)
MIAT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CASC2  (Score: 0.731059)
CASC2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//ELISA//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31258644
Disease Name:Diabetic Nephropathies
Sample:diabetic nephropathy tissues
Dysfunction Pattern:Interaction[HIF1α]
Validated Method:qRT-PCR//ELISA//Western Blot
Description: The results revealed that LINK-A lncRNA and HIF1α were downregulated in patients with diabetic nephropathy, as well as in diabetic patients without complications. LINK-A lncRNA overexpression also promoted HIF1α expression in mouse podocyte cells, while HIF1α overexpression did not significantly affect LINK-A lncRNA expression.
Causality:Yes
Causal Description:LINK-A lncRNA and HIF1α overexpression inhibited the apoptosis of mouse podocyte cells under a high glucose treatment.
Clinical-realted Application: