Entry Detail

General Information

Database ID: LDA0002309
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01123
Full Name:long intergenic non-protein coding RNA 1123
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):109986980End Site(bp):109995281
External Links:
Ensembl ID:ENSG00000204588
Ensembl Transcript ID:N/A
Entrez Gene:440894.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:12   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32423238
Disease Name:Colorectal Neoplasms
Sample:CRC tissues and cell lines
Dysfunction Pattern:regulation[miR-625-5p/LASP1 Axis]
Validated Method:CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:The results show that LINC01123 expression is abnormally elevated in CRC tissues and cell lines.The data indicate that high LINC01123 exerts its oncogenic roles by regulating the miR-625-5p/LASP1 axis in CRC progression.
Causality:Yes
Causal Description:The authors also show that knockdown of LINC01123 inhibits proliferation and invasion in CRC cells.
Clinical-realted Application:High LINC01123 expression closely correlates with poor prognosis, advanced TNM stage, and lymph-node metastasis.

[2] PubMed ID:35325644
Disease Name:Colorectal Neoplasms
Sample:colorectal cancer tumor tissues and cells
Dysfunction Pattern:Interaction(SRSF7)
Validated Method:qRT-PCR//Wound Healing Assay//RNA Pull-Down//Western Blot
Description: LINC01123 was up-regulated in colorectal cancer tumor tissues. The proliferation, invasion and migration ability of colorectal cancer cells were decreased significantly after LINC01123 knockdown, and it may inhibit its expression by interacted with SRSF7, thereby promoting colorectal cancer progression.
Causality:Yes
Causal Description:The proliferation, invasion and migration ability of colorectal cancer cells were decreased significantly after LINC01123 knockdown, and it may inhibit its expression by interacted with SRSF7, thereby promoting colorectal cancer progression.
Clinical-realted Application: