Entry Detail

General Information

Database ID: LDA0002319
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:LINC01116
Full Name:long intergenic non-protein coding RNA 1116
Category:LncRNA
Species:Homo sapiens
Synonyms:TALNEC2
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):176629581End Site(bp):176637574
External Links:
Ensembl ID:ENSG00000163364
Ensembl Transcript ID:N/A
Entrez Gene:375295.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Glioma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Adenocarcinoma of Lung  (Score: 0.999358)
Adenocarcinoma of Lung  (Score: 0.999358)
Glioma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Small Cell Lung Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055752
Disease Name:Small Cell Lung Carcinoma
Category:MeSH
Type:Neoplasms
Define:A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Alias:Small Cell Lung Carcinoma//Small Cell Lung Cancer//Oat Cell Lung Cancer//Small Cell Cancer Of The Lung//Carcinoma, Small Cell Lung//Oat Cell Carcinoma of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
circPVT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
LUADT1  (Score: 0.731059)
LINC01555  (Score: 0.731059)
LINC01116  (Score: 0.731059)
CASC11  (Score: 0.731059)
ZFPM2-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
NEF  (Score: 0.731059)
HIF1A-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//qPCR//Western Blot//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33535997
Disease Name:Small Cell Lung Carcinoma
Sample:SCLC tissues
Dysfunction Pattern:Interaction(miR-93-5p/STAT3)
Validated Method:Transfection//qPCR//Transwell Assay//Western Blot
Description:LINC01116 was highly expressed in SCLC and predicted poor survival. In SCLC tissues, the expression of LINC01116 was positively correlated with STAT3. Bioinformatics analysis revealed that miR-93-5p may target LINC01116.
Causality:Yes
Causal Description:Overexpression of LINC01116 increased STAT3 but did not affect the expression of miR-93-5p. Transwell assay showed that LINC01116 and STAT3 increased cell invasion and migration rates. MiR-93-5p played an suppressed cell behaviors and suppressed the role of LINC01116.
Clinical-realted Application:LINC01116 was highly expressed in SCLC and predicted poor survival.