| | Disease Ontology | MeSH |
| Disease ID: | DOID:0050746 | D020522 |
| Disease Name: | mantle cell lymphoma | Lymphoma, Mantle-Cell |
| Category: | Disease Ontology | MeSH |
| Type: | | Neoplasms |
| Define: | A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. | A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. It accounts for about 5% of adult non-Hodgkin lymphomas in the United States and Europe. The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). |
| Alias: | | Lymphoma, Mantle-Cell//Lymphoma, Mantle Cell//Lymphomas, Mantle-Cell//Mantle-Cell Lymphomas//Lymphocytic Lymphoma, Diffuse, Poorly Differentiated//Lymphocytic Lymphoma, Diffuse, Poorly-Differentiated//Mantle-Zone Lymphoma//Lymphoma, Mantle-Zone//Lymphomas, Mantle-Zone//Mantle Zone Lymphoma//Mantle-Zone Lymphomas//Lymphoma, Lymphocytic, Diffuse, Intermediate Differentiated//Lymphoma, Lymphocytic, Diffuse, Poorly-Differentiated//Lymphoma, Small-Cell, Centrocytic//Mantle-Cell Lymphoma//Mantle Cell Lymphoma//Diffuse Lymphocytic Lymphoma, Poorly-Differentiated//Diffuse Lymphocytic Lymphoma, Poorly Differentiated//Lymphoma, Centrocytic Small-Cell//Centrocytic Small-Cell Lymphoma//Centrocytic Small-Cell Lymphomas//Lymphoma, Centrocytic Small Cell//Lymphomas, Centrocytic Small-Cell//Small-Cell Lymphoma, Centrocytic//Small-Cell Lymphomas, Centrocytic//Lymphoma, Lymphocytic, Intermediate |
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