Entry Detail

General Information

Database ID: LDA0003607
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CRNDE
Full Name:colorectal neoplasia differentially expressed
Category:LncRNA
Species:Homo sapiens
Synonyms:CRNDEP|LINC00180|NCRNA00180|PNAS-108|lincIRX5
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):54918863End Site(bp):54928886
External Links:
Ensembl ID:ENSG00000245694
Ensembl Transcript ID:N/A
Entrez Gene:643911.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:58   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Sepsis  (Score: 0.999893)
Sepsis  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999358)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999358)
Nasopharyngeal carcinoma  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2154D009396
Disease Name:nephroblastomaWilms Tumor
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A kidney cancer that affects the kidneys and typically located_in children.A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Alias:adult nephroblastomaWilms Tumor//Tumor, Wilms//Wilms' Tumor//Tumor, Wilms'//Wilm Tumor//Wilm's Tumor//Wilms Tumor 1//Nephroblastoma//Nephroblastomas//Bilateral Wilms Tumor//Tumor, Bilateral Wilms//Wilms Tumor, Bilateral

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
OSTM1-AS1  (Score: 0.731059)
SOX21-AS1  (Score: 0.731059)
circNCKAP1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
H19  (Score: 0.731059)
HAGLROS  (Score: 0.731059)
hsa_circ_0093741  (Score: 0.731059)
DLEU2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32096178
Disease Name:Wilms Tumor
Sample:tumor tissues
Dysfunction Pattern:regulation[ regulating microRNA-424]
Validated Method:CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay
Description:RT-qPCR results revealed that the expression level of lncRNA CRNDE in tumor tissues of patients with Wilms' tumor was remarkably higher than that of adjacent normal tissues. In addition, CRNDE might accelerate the progression of Wilms' tumor via modulating microRNA-424.
Causality:Yes
Causal Description: Similarly, compared with control group, the proliferation and metastasis abilities of cells in CRNDE knockdown group were remarkably down-regulated (p<0.05). However, opposite results were observed in CRNDE overexpression group.
Clinical-realted Application:Compared with patients with low expression of CRNDE, the risk of lymph node metastasis was significantly higher in patients with high CRNDE expression (p<0.05).