Entry Detail

General Information

Database ID: LDA0003608
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CRNDE
Full Name:colorectal neoplasia differentially expressed
Category:LncRNA
Species:Homo sapiens
Synonyms:CRNDEP|LINC00180|NCRNA00180|PNAS-108|lincIRX5
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):54918863End Site(bp):54928886
External Links:
Ensembl ID:ENSG00000245694
Ensembl Transcript ID:N/A
Entrez Gene:643911.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:58   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Uterine Cervical Neoplasms  (Score: 1)
Sepsis  (Score: 0.999893)
Sepsis  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999358)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999358)
Nasopharyngeal carcinoma  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D008108
Disease Name:Liver Diseases, Alcoholic
Category:MeSH
Type:Digestive System Diseases
Define:Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
Alias:Liver Diseases, Alcoholic//Alcoholic Liver Diseases//Alcoholic Liver Disease//Liver Disease, Alcoholic

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
CRNDE  (Score: 0.731059)
CRNDE  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment
Weak Evidence:

 

Reference

[1] PubMed ID:34633988
Disease Name:Liver Diseases, Alcoholic
Sample:ALD tissues
Dysfunction Pattern:Expression(highly expressed)
Validated Method:In Vivo Experiment
Description: Three lncRNAs (CRNDE, RBMS3-AS3, and LINC01088) were demonstrated to be potentially useful diagnostic markers in ALD. Among them, the expression of CRNDE is up-regulated. The result showed ALD tissues in mice had significantly higher CRNDE levels than normal tissues.
Causality:Yes
Causal Description: In addition, alcohol can induce apoptosis, and knockdown of CRNDE can reduce apoptosis.
Clinical-realted Application: