Entry Detail

General Information

Database ID: LDA0003613
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CREBBP
Full Name:CREB binding protein
Category:LncRNA
Species:Homo sapiens
Synonyms:CBP|KAT3A|MKHK1|RSTS|RSTS1
Chromosome:16
Strand:-
Coordinate:
Start Site(bp):3725054End Site(bp):3880713
External Links:
Ensembl ID:ENSG00000005339
Ensembl Transcript ID:N/A
Entrez Gene:1387.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Liver Cirrhosis  (Score: 0.731059)
Liver Cirrhosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D008103
Disease Name:Liver Cirrhosis
Category:MeSH
Type:Digestive System Diseases
Define:Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Alias:Liver Cirrhosis//Hepatic Cirrhosis//Cirrhosis, Hepatic//Cirrhosis, Liver//Fibrosis, Liver//Liver Fibrosis

 

Disease Association Statistics

Total Associated ncRNA Number:18   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
lnc-ADD3-AS1  (Score: 0.731059)
CREBBP  (Score: 0.731059)
SCARNA10  (Score: 0.731059)
circFBXW4  (Score: 0.731059)
MBI‑52  (Score: 0.731059)
NEAT1  (Score: 0.731059)
lnc-ADD3-AS1  (Score: 0.731059)
CREBBP  (Score: 0.731059)
SCARNA10  (Score: 0.731059)
circFBXW4  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34887753
Disease Name:Liver Cirrhosis
Sample:epatic stellate cell
Dysfunction Pattern:Interaction(hsa-miR-1291/LEFTY2 Axis)
Validated Method:Western Blot//qRT-PCR//PCR//Microarray//RNA Network
Description:For example, circCREBBP was significantly down-regulated in primary hepatic stellate cells (HSCs) and liver tissue of HF mice induced by CCl4 compared to those in the vehicle group. Mechanically, circCREBBP acts as a sponge for hsa-miR-1291 and subsequently promotes LEFTY2 expression.
Causality:Yes
Causal Description:Overexpression of circCREBBP with AAV8-circCREBBP in vivo prevented CCl4-induced HF worsening by reducing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents, liver hydroxyproline levels, collagen deposition, and levels of pro-fibrosis genes and pro-inflammatory cytokines. Furthermore, in vitro function loss and function gain analysis showed that circCREBBP inhibited HSCs activation and proliferation.
Clinical-realted Application: