Entry Detail

General Information

Database ID: LDA0003647
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ciRS-7
Full Name:long intergenic non-protein coding RNA 632
Category:LncRNA
Species:Homo sapiens
Synonyms:ARST|ASINC|BMOR|CDR1-AS|CDR1NAT|CDR1as|MDHDH|ciRS-7
Chromosome:X
Strand:+
Coordinate:
Start Site(bp):140709759End Site(bp):140791357
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:286411.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467D002292
Disease Name:clear cell renal cell carcinomaCarcinoma, Renal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinomaCarcinoma, Renal Cell//Carcinomas, Renal Cell//Renal Cell Carcinomas//Nephroid Carcinoma//Carcinoma, Nephroid//Nephroid Carcinomas//Adenocarcinoma Of Kidney//Adenocarcinoma Of Kidneys//Kidney, Adenocarcinoma Of//Renal Cell Carcinoma//Renal Cell Cancer//Cancer, Renal Cell//Renal Cell Cancers//Adenocarcinoma, Renal//Renal Adenocarcinoma//Renal Adenocarcinomas//Renal Carcinoma//Carcinoma, Renal//Renal Carcinomas//Adenocarcinoma, Renal Cell//Adenocarcinomas, Renal Cell//Renal Cell Adenocarcinoma//Renal Cell Adenocarcinomas//Chromophobe Renal Cell Carcinoma//Sarcomatoid Renal Cell Carcinoma//Papillary Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Chromophil Renal Cell Carcinoma//Clear Cell Renal Cell Carcinoma//Grawitz Tumor//Tumor, Grawitz//Clear Cell Renal Carcinoma//Carcinoma, Hypernephroid//Hypernephroid Carcinoma//Hypernephroid Carcinomas//Hypernephroma//Hypernephromas//Collecting Duct Carcinoma (Kidney)//Carcinoma, Collecting Duct (Kidney)//Carcinomas, Collecting Duct (Kidney)//Collecting Duct Carcinomas (Kidney)//Collecting Duct Carcinoma of the Kidney//Renal Collecting Duct Carcinoma//Collecting Duct Carcinoma//Carcinoma, Collecting Duct//Carcinomas, Collecting Duct//Collecting Duct Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:458   
More Information
Causal ncRNA Number:316
Network:
Top Causal ncRNAs:
SNHG12  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
PVT1  (Score: 1)
PVT1  (Score: 1)
SNHG12  (Score: 1)
SNHG1  (Score: 0.999893)
SNHG1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
MIR4435-2HG  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:32496306
Disease Name:Carcinoma, Renal Cell
Sample:ccRCC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//Western Blot
Description:ciRS-7 was overexpressed in ccRCC tissues compared with that in matched adjacent normal tissues.
Causality:Yes
Causal Description:ciRS-7 knockdown in 786O and 769P cells markedly inhibited their proliferative and invasive abilities.
Clinical-realted Application:In addition, ciRS-7 up-regulation was closely associated with tumor diameter (P = 0.050), clinical stage (P = 0.009), and distant metastasis (P = 0.007).

[2] PubMed ID:34740354
Disease Name:Carcinoma, Renal Cell
Sample:RCC tumor tissues and cell lines
Dysfunction Pattern:Interaction(miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway)
Validated Method:PCR
Description:ciRS-7 was highly expressed in RCC tumor tissues and cell lines, and high ciRS-7 expression correlated with tumor size, high Fuhrman grade and poor survival. Depletion of ciRS-7 significantly inhibited RCC cell proliferation, invasion, tumor growth and metastasis in vivo, while overexpression of ciRS-7 had the opposite effect. Mechanistically, ciRS-7 acts as a "ceRNA" for miR-139-3p to prevent TAGLN degradation and promoting RCC progression and metastasis via the PI3K/AKT signaling pathway. In addition, miR-139-3p mimics or inhibitor could reverse the altered malignant tumor behavior caused by ciRS-7 overexpression or silencing. Furthermore, the PBAE/siciRS-7 nanocomplexes could significantly inhibit RCC tumor progression and metastasis in vivo. ciRS-7 acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis. Drug development of PBAE/si-ciRS-7 nanocomplexes targeting ciRS-7 may represent a promising gene therapeutic strategy for RCC.
Causality:Yes
Causal Description:In addition, miR-139-3p mimics or inhibitor could reverse the altered malignant tumor behavior caused by ciRS-7 overexpression or silencing.
Clinical-realted Application: