Entry Detail

General Information

Database ID: LDA0003675
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CLSPN
Full Name:claspin
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):35720213End Site(bp):35769978
External Links:
Ensembl ID:ENSG00000092853
Ensembl Transcript ID:N/A
Entrez Gene:63967.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Glioblastoma  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3068D005909
Disease Name:glioblastomaGlioblastoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A malignant astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes.A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
Alias:GBM//adult glioblastoma multiforme//grade IV adult Astrocytic tumor//primary glioblastoma multiforme//spongioblastoma multiformeGlioblastoma//Glioblastomas//Astrocytoma, Grade IV//Astrocytomas, Grade IV//Grade IV Astrocytoma//Grade IV Astrocytomas//Glioblastoma Multiforme//Giant Cell Glioblastoma//Giant Cell Glioblastomas//Glioblastoma, Giant Cell//Glioblastomas, Giant Cell

 

Disease Association Statistics

Total Associated ncRNA Number:296   
More Information
Causal ncRNA Number:252
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
LINC-ROR  (Score: 0.999893)
MALAT1  (Score: 0.999893)
HOTAIRM1  (Score: 0.999893)
LINC-ROR  (Score: 0.999893)
MALAT1  (Score: 0.999893)
HOTAIRM1  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0029426  (Score: 0.985791)
DLGAP1-AS1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//qPCR//Flow Cytometry//RIP//PCR//IP//Transwell Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34269180
Disease Name:Glioblastoma
Sample:GBM tumor tissues and cells
Dysfunction Pattern:Interaction(miR-370-3p-USP39 pathway)
Validated Method:RNA Pull-Down//Western Blot//Transfection//qPCR//Flow Cytometry//RIP//IF//PCR//IP//Transwell Assay
Description:First, we examined expression of circCLSPN using GSE109569 database and RT-qPCR, and circCLSPN level was upregulated in human GBM tumor tissues and cells (A172 and LN18); moreover, circCLSPN showed a stable structure stability. According to dual-luciferase reporter assay and RNA pull-down assay, miR-370-3p was identified to be targeted and sponged by circCLSPN, and further targeted and negatively regulated USP39.
Causality:Yes
Causal Description:Consequently, circCLSPN silencing suppressed cell viability, colony formation ability, cell cycle progression, migration, and invasion of A172 and LN18 cells in vitro, and promoted apoptosis rate. Allied with those were decreased B cell lymphoma-2 (Bcl-2), matrix metalloproteinase-2 (MMP2) and MMP9 expression, and elevated Bcl-2-associated X protein (Bax) level.
Clinical-realted Application: