Entry Detail

General Information

Database ID: LDA0003676
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CLRN1-AS1
Full Name:CLRN1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CLRN1OS|UCRP
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):150972678End Site(bp):151080726
External Links:
Ensembl ID:ENSG00000239265
Ensembl Transcript ID:N/A
Entrez Gene:116933.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Prolactinoma  (Score: 0.731059)
Prolactinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D015175
Disease Name:Prolactinoma
Category:MeSH
Type:Neoplasms
Define:A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.
Alias:Prolactinoma//Prolactinomas//Lactotroph Adenoma//Adenoma, Lactotroph//Adenomas, Lactotroph//Lactotroph Adenomas//Prolactinoma, Familial//PRL-Secreting Pituitary Adenoma//PRL Secreting Pituitary Adenoma//PRL-Secreting Pituitary Adenomas//Pituitary Adenoma, PRL-Secreting//Pituitary Adenomas, PRL-Secreting//Prolactin-Producing Pituitary Adenoma//Pituitary Adenoma, Prolactin-Producing//Pituitary Adenomas, Prolactin-Producing//Prolactin Producing Pituitary Adenoma//Prolactin-Producing Pituitary Adenomas//Prolactin-Secreting Pituitary Adenoma//Prolactin Secreting Pituitary Adenoma//Adenoma, Prolactin-Secreting, Pituitary//Pituitary Adenoma, Prolactin-Secreting//Pituitary Adenoma, Prolactin Secreting//Pituitary Adenomas, Prolactin-Secreting//Prolactin-Secreting Pituitary Adenomas//Microprolactinoma//Microprolactinomas//Macroprolactinoma//Macroprolactinomas

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
CLRN1-AS1  (Score: 0.731059)
CLRN1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:31235696
Disease Name:Prolactinoma
Sample:pituitary prolactinoma tissues
Dysfunction Pattern:Regulation[Wnt/β-catenin signaling pathway]
Validated Method:RNA Pull-Down//Western Blot//CCK8//qRT-PCR//RIP//FISH//Luciferase Report Assay//Microarray//Colony Formation Assay//EdU Staining//ChIP
Description:LncRNA clarin 1 antisense RNA 1 (CLRN1-AS1) was downregulated in 42 patient samples and inactivated the Wnt/β-catenin signaling pathway. In summary, this study revealed that FOXP1-induced CLRN1-AS1 regulated cellular functions in pituitary prolactinoma by sponging miR-217 to release the DKK1/Wnt/β-catenin signaling pathway.
Causality:Yes
Causal Description:Functionally, CLRN1-AS1 suppressed cell proliferation, promoted apoptosis, and inhibited autophagy.
Clinical-realted Application: