Entry Detail

General Information

Database ID: LDA0003680
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ciRS-7
Full Name:long intergenic non-protein coding RNA 632
Category:LncRNA
Species:Homo sapiens
Synonyms:ARST|ASINC|BMOR|CDR1-AS|CDR1NAT|CDR1as|MDHDH|ciRS-7
Chromosome:X
Strand:+
Coordinate:
Start Site(bp):140709759End Site(bp):140791357
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:286411.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Renal Cell  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.731059)
Arthritis, Rheumatoid  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Osteoarthritis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8398D010003
Disease Name:osteoarthritisOsteoarthritis
Category:Disease OntologyMeSH
Type:Musculoskeletal Diseases
Define:An arthritis that has_material_basis_in worn out cartilage located_in joint.A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
Alias:Osteoarthrosis and allied disorder//degenerative arthritis//degenerative joint disease//hypertrophic arthritis//osteoarthrosisOsteoarthritis//Osteoarthritides//Osteoarthrosis//Osteoarthroses//Arthritis, Degenerative//Arthritides, Degenerative//Degenerative Arthritides//Degenerative Arthritis//Arthrosis//Arthroses//Osteoarthrosis Deformans

 

Disease Association Statistics

Total Associated ncRNA Number:784   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
MCM3AP-AS1  (Score: 0.985791)
hsa_circ_0005567  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
CASC2  (Score: 0.985791)
PVT1  (Score: 0.985791)
XIST  (Score: 0.985791)
hsa_circ_0032131  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//MTT//PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:30925324
Disease Name:Osteoarthritis
Sample:blood
Dysfunction Pattern:Regulation[ciRS-7/miR-7 axis ]
Validated Method:Western Blot//qRT-PCR//MTT//PCR//ELISA
Description:Decreased ciRS-7 expression and increased miR-7 expression were observed in OA blood samples. These findings demonstrate that the ciRS-7/miR-7 axis can possibly serve as a regulator in mediating proliferation, apoptosis and inflammation in chondrocytes in the process of OA development.
Causality:Yes
Causal Description:Transfection of ciRS-7 siRNA and miR-7 mimic enhanced the impact of IL-1β on inflammatory cytokine release and cell apoptosis as quantified using ELISA and flow cytometry. Conversely, ciRS-7 cDNA and miR-7 inhibitor induced the reverse effect.
Clinical-realted Application: