Entry Detail

General Information

Database ID: LDA0003685
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CYTOR
Full Name:cytoskeleton regulator RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C2orf59|LINC00152|NCRNA00152
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):87455427End Site(bp):87521518
External Links:
Ensembl ID:ENSG00000222041
Ensembl Transcript ID:N/A
Entrez Gene:112597.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:52   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4467D002292
Disease Name:clear cell renal cell carcinomaCarcinoma, Renal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope.A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
Alias:Clear cell carcinoma of kidney//clear cell kidney carcinoma//conventional (Clear cell) renal cell carcinoma//conventional renal cell carcinoma//renal clear cell carcinomaCarcinoma, Renal Cell//Carcinomas, Renal Cell//Renal Cell Carcinomas//Nephroid Carcinoma//Carcinoma, Nephroid//Nephroid Carcinomas//Adenocarcinoma Of Kidney//Adenocarcinoma Of Kidneys//Kidney, Adenocarcinoma Of//Renal Cell Carcinoma//Renal Cell Cancer//Cancer, Renal Cell//Renal Cell Cancers//Adenocarcinoma, Renal//Renal Adenocarcinoma//Renal Adenocarcinomas//Renal Carcinoma//Carcinoma, Renal//Renal Carcinomas//Adenocarcinoma, Renal Cell//Adenocarcinomas, Renal Cell//Renal Cell Adenocarcinoma//Renal Cell Adenocarcinomas//Chromophobe Renal Cell Carcinoma//Sarcomatoid Renal Cell Carcinoma//Papillary Renal Cell Carcinoma//Renal Cell Carcinoma, Papillary//Chromophil Renal Cell Carcinoma//Clear Cell Renal Cell Carcinoma//Grawitz Tumor//Tumor, Grawitz//Clear Cell Renal Carcinoma//Carcinoma, Hypernephroid//Hypernephroid Carcinoma//Hypernephroid Carcinomas//Hypernephroma//Hypernephromas//Collecting Duct Carcinoma (Kidney)//Carcinoma, Collecting Duct (Kidney)//Carcinomas, Collecting Duct (Kidney)//Collecting Duct Carcinomas (Kidney)//Collecting Duct Carcinoma of the Kidney//Renal Collecting Duct Carcinoma//Collecting Duct Carcinoma//Carcinoma, Collecting Duct//Carcinomas, Collecting Duct//Collecting Duct Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:458   
More Information
Causal ncRNA Number:316
Network:
Top Causal ncRNAs:
SNHG12  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
PVT1  (Score: 1)
PVT1  (Score: 1)
SNHG12  (Score: 1)
SNHG1  (Score: 0.999893)
SNHG1  (Score: 0.999893)
HOTAIR  (Score: 0.985791)
MIR4435-2HG  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35597301
Disease Name:Carcinoma, Renal Cell
Sample:RCC tissues and cell lines
Dysfunction Pattern:Interaction(miR-136-5p/MAT2B axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//ChIP
Description:LncRNA CYTOR was up-regulated in RCC tissues and cell lines, and miR-136-5p was down-regulated in renal carcinoma cell lines and tissues.miR-136-5p was sponged by lncRNA CYTOR, which negatively regulated the development of RCC. MAT2B was a target gene of miR-136-5p. MAT2B protein interacted directly with BAG3 protein to affect the proliferation, invasion and apoptosis of RCC cells.
Causality:Yes
Causal Description:Downregulation of CYTOR inhibited cell proliferation and invasion and promoted apoptosis. miR-136-5p was sponged by lncRNA CYTOR, which negatively regulated the development of RCC. MAT2B was a target gene of miR-136-5p. MAT2B protein interacted directly with BAG3 protein to affect the proliferation, invasion and apoptosis of RCC cells.
Clinical-realted Application: