Entry Detail

General Information

Database ID: LDA0003706
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DANCR
Full Name:Angelman syndrome chromosome region
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000226950
Ensembl Transcript ID:N/A
Entrez Gene:282.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:62   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2513D002280
Disease Name:basal cell carcinomaCarcinoma, Basal Cell
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A skin carcinoma affecting basal cells.A malignant skin neoplasm that seldom metastasizes but has potentialities for local invasion and destruction. Clinically it is divided into types: nodular, cicatricial, morphaic, and erythematoid (pagetoid). They develop on hair-bearing skin, most commonly on sun-exposed areas. Approximately 85% are found on the head and neck area and the remaining 15% on the trunk and limbs. (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1471)
Alias:Basal cell cancer//Basal cell carcinoma of skin//Basal cell neoplasm//Basal cell tumor//Epithelioma basal cell//Rodent ulcer//malignant Basal cell neoplasm//malignant basal cell tumorCarcinoma, Basal Cell//Basal Cell Carcinoma//Basal Cell Carcinomas//Carcinomas, Basal Cell//Rodent Ulcer//Rodent Ulcers//Ulcers, Rodent//Ulcer, Rodent//Epithelioma, Basal Cell//Basal Cell Epithelioma//Basal Cell Epitheliomas//Epitheliomas, Basal Cell//Carcinoma, Basal Cell, Pigmented

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
DANCR  (Score: 0.731059)
DANCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Wound Healing Assay//Tunel//qRT-PCR//Cell Proliferation Assay//Cell Apoptosis Assay//cell invasion assay
Weak Evidence:

 

Reference

[1] PubMed ID:35642174
Disease Name:Carcinoma, Basal Cell
Sample:BCC tissues
Dysfunction Pattern:Interaction(PTCH)
Validated Method:In Vivo Experiment//RNA Pull-Down//cell invasion assay//Western Blot//Wound Healing Assay//Tunel//qRT-PCR//Cell Apoptosis Assay//Cell Proliferation Assay
Description:ANCR and Hedgehog pathway were more highly expressed in BCC tissues than in adjacent normal tissues. An RNA pull-down assay further revealed that ANCR is specifically bound to PTCH. In vivo experiments also showed that ANCR overexpression significantly increased tumor growth and decreased apoptosis, which was reversed by cyclopamine, a specific inhibitor of the Hedgehog signaling pathway.
Causality:Yes
Causal Description:ANCR overexpression substantially promoted BCC cell proliferation, invasion, and migration, inhibited apoptosis, and up-regulated BCL2 and decreased the expression of BAX and Cleaved-caspase3 proteins. Additionally, the upregulation of N-cadherin, vimentin, β-catenin, PTCH, GLI1, and SMO expression, and downregulation of E-cadherin expression were observed after ANCR overexpression. Moreover, ANCR knockdown had the opposite effects.
Clinical-realted Application: