Entry Detail


General Information

Database ID: LDA0003713
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CYTOR
Full Name:cytoskeleton regulator RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C2orf59|LINC00152|NCRNA00152
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):87455427End Site(bp):87521518
External Links:
Ensembl ID:ENSG00000222041
Ensembl Transcript ID:N/A
Entrez Gene:112597.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:52   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D007822
Disease Name:Laryngeal Neoplasms
Category:MeSH
Type:Neoplasms
Define:Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.
Alias:Laryngeal Neoplasms//Neoplasms, Laryngeal//Laryngeal Neoplasm//Neoplasm, Laryngeal//Larynx Neoplasms//Larynx Neoplasm//Neoplasm, Larynx//Neoplasms, Larynx//Cancer of Larynx//Larynx Cancers//Laryngeal Cancer//Cancer, Laryngeal//Cancers, Laryngeal//Laryngeal Cancers//Larynx Cancer//Cancer, Larynx//Cancers, Larynx//Cancer of the Larynx

 

Disease Association Statistics

Total Associated ncRNA Number:44   
More Information
Causal ncRNA Number:40
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
PCAT19  (Score: 0.731059)
circRANBP9  (Score: 0.731059)
PCAT1  (Score: 0.731059)
SBF2-AS1  (Score: 0.731059)
CYTOR  (Score: 0.731059)
LINC00888  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32266320
Disease Name:Laryngeal Neoplasms
Sample:LSCC tissues
Dysfunction Pattern:interaction[Sponging MiR-613]
Validated Method:qRT-PCR//Luciferase Report Assay
Description:LINC00152 levels in LSCC tissues were significantly higher than those in adjacent normal tissue, and patients with lymph node metastasis or an advanced clinical stage displayed higher LINC00152 expression.LINC00152 exerts an oncogenic effect on the tumorigenesis of LSCC by sponging miR-613 and may serve as a potential target for treating LSCC.
Causality:Yes
Causal Description: Moreover, siRNA-mediated LINC00152 knockdown significantly inhibited the proliferation, migration and invasion of LSCC cells and induced apoptosis in those cells.
Clinical-realted Application:LINC00152 levels in LSCC tissues were significantly higher than those in adjacent normal tissue, and patients with lymph node metastasis or an advanced clinical stage displayed higher LINC00152 expression.