Entry Detail

General Information

Database ID: LDA0003714
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CYTOR
Full Name:cytoskeleton regulator RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:C2orf59|LINC00152|NCRNA00152
Chromosome:2
Strand:+
Coordinate:
Start Site(bp):87455427End Site(bp):87521518
External Links:
Ensembl ID:ENSG00000222041
Ensembl Transcript ID:N/A
Entrez Gene:112597.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:52   
More Information
Causal Disease Number:46
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Glioma  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2725
Disease Name:capillary hemangioma
Category:Disease Ontology
Type:Neoplasms
Define:A hemangioma that is characterized by the presence of capillary-sized vascular channels without prominent epithelioid endothelial cells.
Alias:Congenital vascular hamartoma//Congenital vascular naevus//Infantile hemangioma//Juvenile hemangioma//Strawberry haemangioma//Strawberry nevus//Strawberry nevus of skin//cellular hemangioma of Infancy

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
CYTOR  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
CYTOR  (Score: 0.985791)
NEAT1  (Score: 0.985791)
TUG1  (Score: 0.731059)
TUG1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//ISH//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31542613
Disease Name:capillary hemangioma
Sample:infantile skin hemangioma tissues
Dysfunction Pattern:Interaction[miR-139-5p]
Validated Method:Western Blot//ISH//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay
Description:Linc00152 was overexpressed in the proliferating-phase hemangioma tissues when compared with that in involuting-phase. ubsequent analysis revealed that linc00152 bound with miR-139-5p and linc00152 expression was inversely correlated with the level of miR-139-5p in IH. Same effects of miR-139-5p transfection on HemECs cells were observed as downregulation of linc00152. Moreover, tumor protein D52 (TPD52) was confirmed to be the target of miR-139-5p. Besides, the anti-tumor effect of linc00152 silence on hemangioma cell was reversed by rexpression of TPD52.
Causality:Yes
Causal Description:Downregulation of linc00152 strikingly suppressed the cell viability, migration and invasion of hemangioma cells. Furthermore, silence of linc00152 repressed the growth and lung metastasis of hemangioma cell in vivo.
Clinical-realted Application:

[2] PubMed ID:30851338
Disease Name:capillary hemangioma
Sample:IH tissues
Dysfunction Pattern:Regulation[Akt/mTOR and Notch1 pathways ]
Validated Method:CCK8//qRT-PCR//Western Blot
Description:The results demonstrated Linc00152 was up-regulated in clinical IH tissues and HemECs.Knockdown of Linc00152 suppressed HemECs proliferation and induced apoptosis via inhibiting Akt/mTOR and Notch1 signaling pathways.
Causality:Yes
Causal Description: Knockdown of Linc00152 in HemECs suppressed the activation of Akt/mTOR and Notch1 signaling pathways and caused reduction in cell proliferation and Ki67 expression in HemECs. Besides, Linc00152 knockdown resulted in a significant increase in apoptotic rate, caspase-3/7 activity, and Bax expression level, as well as a decrease in Bcl-2 expression level.
Clinical-realted Application: