Entry Detail

General Information

Database ID: LDA0003715
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CTBP1-DT
Full Name:CTBP1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf42|CTBP1-AS1|CTBP1-AS2
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):1249440End Site(bp):1253007
External Links:
Ensembl ID:ENSG00000196810
Ensembl Transcript ID:N/A
Entrez Gene:92070.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Pancreatic Carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:34887384
Disease Name:Ovarian Neoplasms
Sample:a cohort of HGSOC tissues
Dysfunction Pattern:Interaction(miR-188-5p/MAP3K3 axis)
Validated Method:In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Bioinformatics Analysis//ChIP
Description:Based on public databases and bioinformatics analyses, the overexpression of lncRNA CTBP1-DT in HGSOC tissues was detected and validated in a cohort of HGSOC tissues. Mechanistically, lncRNA CTBP1-DT could competitively bind to miR-188-5p to protect MAP3K3 from degradation. Moreover, our results revealed that ETV5 could specifically interact with the promoter of lncRNA CTBP1-DT and activate its transcription.
Causality:Yes
Causal Description:Overexpression of lncRNA CTBP1-DT promoted malignant biological behaviour of HGSOC cells, whereas its depletion induced growth arrest of HGSOC cells by vitro and in vivo assays.
Clinical-realted Application:High expression of lncRNA CTBP1-DT was associated with poor prognosis and was an independent risk factor for survival.

[2] PubMed ID:32711584
Disease Name:Ovarian Neoplasms
Sample:OC tissues
Dysfunction Pattern:regulation[miR-216a/ PTEN]
Validated Method:qRT-PCR//Luciferase Report Assay
Description:We found that CTBP1-AS2 was downregulated in OC and predicted poor survival. CTBP1-AS2 regulates miR-216a/PTEN to suppress OC cell proliferation.
Causality:Yes
Causal Description:CTBP1-AS2 and PTEN overexpression resulted in the reduced proliferation rate of OC cells and reduced effects of miR-216a overexpression.
Clinical-realted Application:We found that CTBP1-AS2 was downregulated in OC and predicted poor survival.