Entry Detail

General Information

Database ID: LDA0003726
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CTBP1-DT
Full Name:CTBP1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf42|CTBP1-AS1|CTBP1-AS2
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):1249440End Site(bp):1253007
External Links:
Ensembl ID:ENSG00000196810
Ensembl Transcript ID:N/A
Entrez Gene:92070.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Pancreatic Carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4905C562463
Disease Name:pancreatic carcinomaPancreatic Carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pancreas cancer that derives_from epithelial cells located_in the exocrine pancreas.Carcinoma that originates from the EXOCRINE PANCREAS; most pancreatic carcinomas are ADENOCARCINOMAS. Somatic mutations in KRAS, TP53, MADH4, and STK11 genes, and germline mutations in BRCA2 and PALB2 genes have been identified. OMIM: 260350
Alias:Exocrine pancreas carcinoma//carcinoma of pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:24   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
SNHG11  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
LINC01963  (Score: 0.731059)
CTBP1-DT  (Score: 0.731059)
DNAH17-AS1  (Score: 0.731059)
SNHG17  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
MIAT  (Score: 0.731059)
TMPO-AS1  (Score: 0.731059)
HCG11  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35039872
Disease Name:Pancreatic Carcinoma
Sample:pancreatic carcinoma tissues and cell line
Dysfunction Pattern:Interaction(miR-141-3p and USP22 )
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Transwell Assay
Description: It was demonstrated that CTBP1-AS2 expression was markedly increased in pancreatic carcinoma tissues and cell lines. In terms of mechanism, it was found that CTBP1‑AS2 adsorbed miR‑141‑3p as a molecular sponge to upregulate the expression level of USP22.
Causality:Yes
Causal Description:High CTBP1‑AS2 expression was associated with advanced clinical stage and lymph node metastasis of patients.
Clinical-realted Application:High CTBP1‑AS2 expression was associated with advanced clinical stage and lymph node metastasis of patients.