Entry Detail

General Information

Database ID: LDA0003728
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CTBP1-DT
Full Name:CTBP1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf42|CTBP1-AS1|CTBP1-AS2
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):1249440End Site(bp):1253007
External Links:
Ensembl ID:ENSG00000196810
Ensembl Transcript ID:N/A
Entrez Gene:92070.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Pancreatic Carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//migration assay
Weak Evidence:

 

Reference

[1] PubMed ID:33150795
Disease Name:Glioma
Sample:glioma tissues
Dysfunction Pattern:regulation[miR-370-3p-Wnt7a axis]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//migration assay
Description:The lncRNA CTBP1-AS2 had increased expression profiles in tumor tissues, which is associated with poor prognosisThis study provides new insights that a novel lncRNA, CTBP1-AS2, regulates EMT of glioma by modulating the miR-370-3p-Wnt7a axis.
Causality:Yes
Causal Description:In detail, CTBP1-AS2 knockdown decreased proliferation and migration phenotypes in both U87-MG and LN229 cells.
Clinical-realted Application:The lncRNA CTBP1-AS2 had increased expression profiles in tumor tissues, which is associated with poor prognosis