Entry Detail

General Information

Database ID: LDA0003737
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CTBP1-DT
Full Name:CTBP1 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:C4orf42|CTBP1-AS1|CTBP1-AS2
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):1249440End Site(bp):1253007
External Links:
Ensembl ID:ENSG00000196810
Ensembl Transcript ID:N/A
Entrez Gene:92070.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Ovarian Neoplasms  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Pancreatic Carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Pancreatic Carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//TUNEL//CCK8//RIP//qRT-PCR//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32742190
Disease Name:Uterine Cervical Neoplasms
Sample:cell lines
Dysfunction Pattern:regulation[miR-3163 ,ZNF217]
Validated Method:RNA Pull-Down//TUNEL//CCK8//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:CTBP1-AS2 was significantly overexpressed in CC cell lines.CTBP1-AS2 regulates CC progression via sponging miR-3163 to up-regulate ZNF217.
Causality:Yes
Causal Description:Knockdown of CTBP1-AS2 curbed cell proliferation, migration and invasion, while stimulated cell apoptosis in vitro. CTBP1-AS2 facilitated xenograft tumor growth in vivo.
Clinical-realted Application: