Entry Detail

General Information

Database ID: LDA0003745
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CHEK1
Full Name:checkpoint kinase 1
Category:LncRNA
Species:Homo sapiens
Synonyms:CHK1
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):125625136End Site(bp):125681124
External Links:
Ensembl ID:ENSG00000149554
Ensembl Transcript ID:N/A
Entrez Gene:1111.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Multiple Myeloma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9538D009101
Disease Name:multiple myelomaMultiple Myeloma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid neoplasm that is located_in the plasma cells in bone marrow.A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Alias:Multiple Myeloma//Multiple Myelomas//Myelomas, Multiple//Myeloma, Multiple//Myeloma, Plasma-Cell//Myeloma, Plasma Cell//Myelomas, Plasma-Cell//Plasma-Cell Myeloma//Plasma-Cell Myelomas//Myelomatosis//Myelomatoses//Plasma Cell Myeloma//Cell Myeloma, Plasma//Cell Myelomas, Plasma//Myelomas, Plasma Cell//Plasma Cell Myelomas//Kahler Disease//Disease, Kahler//Myeloma-Multiple//Myeloma Multiple//Myeloma-Multiples

 

Disease Association Statistics

Total Associated ncRNA Number:180   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
CDKN2B-AS1  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
hsa_circ_0007841  (Score: 0.985791)
lnc-TCF7  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Co-IP//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34090465
Disease Name:Multiple Myeloma
Sample:MM cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Co-IP//Cell Proliferation Assay//Cell Cycle Assay//Colony Formation Assay//IF
Description:We demonstrated that CHEK1 expression was significantly increased in human MM samples relative to normal plasma cells, and that in MM patients, high CHEK1 expression was associated with poor outcomes. Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo. CHEK1-mediated increases in cell proliferation and drug resistance were due in part to CHEK1-induced CIN. CHEK1 activated CIN, partly by phosphorylating CEP170. Interestingly, CHEK1 promoted osteoclast differentiation by upregulating NFATc1 expression. Intriguingly, we discovered that MM cells expressed circCHEK1_246aa, a circular CHEK1 RNA, which encoded and was translated to the CHEK1 kinase catalytic center. Transfection of circCHEK1_246aa increased MM CIN and osteoclast differentiation similarly to CHEK1 overexpression, suggesting that MM cells could secrete circCHEK1_246aa in the BM niche to increase the invasive potential of MM cells and promote osteoclast differentiation.
Causality:Yes
Causal Description:Increased CHEK1 expression induced MM cellular proliferation and evoked drug-resistance in vitro and in vivo.
Clinical-realted Application:and that in MM patients, high CHEK1 expression was associated with poor outcomes.