Entry Detail

General Information

Database ID: LDA0003770
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CD82-AS1
Full Name:N/A
Category:LncRNA
Species:Homo sapiens
Synonyms:N/A
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:ENSG00000254693
Entrez Gene:N/A
NONCODE ID:NONHSAT160290
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Diabetic Nephropathies  (Score: 0.731059)
Diabetic Nephropathies  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003928
Disease Name:Diabetic Nephropathies
Category:MeSH
Type:Urogenital Diseases
Define:KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Alias:Diabetic Nephropathies//Nephropathies, Diabetic//Nephropathy, Diabetic//Diabetic Nephropathy//Diabetic Kidney Disease//Diabetic Kidney Diseases//Kidney Disease, Diabetic//Kidney Diseases, Diabetic//Diabetic Glomerulosclerosis//Glomerulosclerosis, Diabetic//Intracapillary Glomerulosclerosis//Nodular Glomerulosclerosis//Glomerulosclerosis, Nodular//Kimmelstiel-Wilson Syndrome//Kimmelstiel Wilson Syndrome//Syndrome, Kimmelstiel-Wilson//Kimmelstiel-Wilson Disease//Kimmelstiel Wilson Disease

 

Disease Association Statistics

Total Associated ncRNA Number:72   
More Information
Causal ncRNA Number:58
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.999998)
MALAT1  (Score: 0.999998)
MIAT  (Score: 0.985791)
MIAT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
circHIPK3  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CASC2  (Score: 0.731059)
CASC2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Migration Assay//RIP//qRT-PCR//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35493610
Disease Name:Diabetic Nephropathies
Sample:DKD patients and high-glucose-induced human podocytes
Dysfunction Pattern:Interaction(HuR)
Validated Method:Western Blot//Transfection//Migration Assay//qRT-PCR//RIP//Transwell Assay
Description:In this study, we found that the expression of lncRNA 254693 was increased in both DKD patients and high-glucose-induced human podocytes. Then, we did bioinformatics analysis via RBPDB and found that lncRNA 254693 can combine with HuR, a RNA binding protein. Meanwhile, immunofluorescence and in situ hybridization double staining was used to prove the existence of colocalization between them. Intriguingly, lncRNA 254693 knockdown decreased HuR levels, while HuR knockdown also decreased the level of lncRNA 254693 and its stability.
Causality:Yes
Causal Description:Downregulation of lncRNA 254693 remarkably reversed the elevation of inflammation, apoptosis, and podocyte injury caused by high glucose.
Clinical-realted Application: