Entry Detail

General Information

Database ID: LDA0003772
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CD27-AS1
Full Name:CD27 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):6439001End Site(bp):6451517
External Links:
Ensembl ID:ENSG00000215039
Ensembl Transcript ID:N/A
Entrez Gene:678655.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Leukemia, Myeloid, Acute  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9119D015470
Disease Name:acute myeloid leukemiaLeukemia, Myeloid, Acute
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Alias:AML - acute Myeloid Leukemia//Leukemia, Myelocytic, acute//acute myeloblastic leukaemia//acute myeloblastic leukemia//acute myelogenous leukaemia//acute myelogenous leukemia//acute myeloid leukaemiaLeukemia, Myeloid, Acute//Acute Myeloid Leukemia//Acute Myeloid Leukemias//Leukemias, Acute Myeloid//Myeloid Leukemias, Acute//ANLL//Leukemia, Acute Myelogenous//Leukemia, Acute Myeloid//Leukemia, Myeloblastic, Acute//Leukemia, Myelocytic, Acute//Leukemia, Myelogenous, Acute//Leukemia, Nonlymphoblastic, Acute//Leukemia, Nonlymphocytic, Acute//Myeloblastic Leukemia, Acute//Acute Myeloblastic Leukemia//Acute Myeloblastic Leukemias//Leukemia, Acute Myeloblastic//Leukemias, Acute Myeloblastic//Myeloblastic Leukemias, Acute//Myelocytic Leukemia, Acute//Acute Myelocytic Leukemia//Acute Myelocytic Leukemias//Leukemia, Acute Myelocytic//Leukemias, Acute Myelocytic//Myelocytic Leukemias, Acute//Myelogenous Leukemia, Acute//Myeloid Leukemia, Acute//Nonlymphoblastic Leukemia, Acute//Acute Nonlymphoblastic Leukemia//Acute Nonlymphoblastic Leukemias//Leukemia, Acute Nonlymphoblastic//Leukemias, Acute Nonlymphoblastic//Nonlymphoblastic Leukemias, Acute//Nonlymphocytic Leukemia, Acute//Acute Nonlymphocytic Leukemia//Acute Nonlymphocytic Leukemias//Leukemia, Acute Nonlymphocytic//Leukemias, Acute Nonlymphocytic//Nonlymphocytic Leukemias, Acute//Acute Myelogenous Leukemia//Acute Myelogenous Leukemias//Leukemias, Acute Myelogenous//Myelogenous Leukemias, Acute//Myeloid Leukemia, Acute, M1//Leukemia, Myeloid, Acute, M1//Acute Myeloid Leukemia without Maturation//Leukemia, Myeloid, Acute, M2//Myeloid Leukemia, Acute, M2//Acute Myeloid Leukemia with Maturation

 

Disease Association Statistics

Total Associated ncRNA Number:196   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
TUG1  (Score: 0.999998)
TUG1  (Score: 0.999998)
MVIH  (Score: 0.999893)
SNHG5  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
SNHG5  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34006845
Disease Name:Leukemia, Myeloid, Acute
Sample:AML patients (N = 40)
Dysfunction Pattern:Interaction(miR-224-5p/PBX3 signaling)
Validated Method:qRT-PCR//Luciferase Report Assay
Description:In present study, we found that the expression of CD27-AS1 examined by quantitative real-time PCR was markedly increased in the AML patients (N = 40) compared with healthy volunteers (N = 40). Additionally, CD27-AS1 was proved to increase PBX3 expression through sponging miR-224-5p. CD27-AS1 knockdown blocked the MAPK signaling through PBX3 silencing and further inhibited the cell growth of AML cells.
Causality:Yes
Causal Description:Furthermore, downregulation of CD27-AS1 in AML cells suppressed proliferative ability, arrested cell cycle in G0/G1 phase, and induced apoptosis. However, CD27-AS1 overexpression further enhanced the malignant phenotype of AML cells.
Clinical-realted Application:The overall survival time was significantly shorter in patients with higher CD27-AS1 expression than that in patients with lower CD27-AS1 (P < 0.01).