Entry Detail

General Information

Database ID: LDA0003784
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CCHE1
Full Name:cervical carcinoma expressed PCNA regulatory lncRNA
Category:LncRNA
Species:Homo sapiens
Synonyms:CCHE1|lncRNA-CCHE1
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):59173963End Site(bp):59176464
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:105682749.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Urinary Bladder Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
pancreatic adenocarcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4074
Disease Name:pancreatic adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A pancreatic carcinoma that derives_from epithelial cells of glandular origin.
Alias:pancreas adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
CCHE1  (Score: 0.731059)
circMYBL2  (Score: 0.731059)
LINC01139  (Score: 0.731059)
LINC01857  (Score: 0.731059)
LINC00857  (Score: 0.731059)
lnc-IUR  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:ELISA//Western Blot//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31423182
Disease Name:pancreatic adenocarcinoma
Sample:blood
Dysfunction Pattern:Interaction[ROCK1]
Validated Method:ELISA//Transwell Assay//Western Blot
Description:The results of the present study demonstrated that, compared with healthy controls, CCHE1 and ROCK1 were upregulated in the serum of patients with metastatic pancreatic adenocarcinoma.ROCK1 small interfering RNA-induced silencing partially reversed the enhancing effects of CCHE1 overexpression on cancer cell migration and invasion. Therefore, lncRNA-CCHE1 may be involved in migration and invasion but not in proliferation of pancreatic adenocarcinoma cells, possibly by interacting with ROCK1.
Causality:Yes
Causal Description: CCHE1 overexpression promoted the migration and invasion of human pancreatic adenocarcinoma cell lines, but no significant effects on cell proliferation were identified.
Clinical-realted Application: