Entry Detail

General Information

Database ID: LDA0003786
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CHASERR
Full Name:CHD2 adjacent suppressive regulatory RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01578
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):92882843End Site(bp):92898747
External Links:
Ensembl ID:ENSG00000272888
Ensembl Transcript ID:N/A
Entrez Gene:100507217.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colonic Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:219D003110
Disease Name:colon cancerColonic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A colorectal cancer that is located_in the colon.Tumors or cancer of the COLON.
Alias:Colonic Neoplasms//Colonic Neoplasm//Neoplasm, Colonic//Neoplasms, Colonic//Colon Neoplasms//Colon Neoplasm//Neoplasm, Colon//Neoplasms, Colon//Cancer of Colon//Colon Cancers//Colon Cancer//Cancer, Colon//Cancers, Colon//Cancer of the Colon//Colonic Cancer//Cancer, Colonic//Cancers, Colonic//Colonic Cancers//Colon Adenocarcinoma//Adenocarcinoma, Colon//Adenocarcinomas, Colon//Colon Adenocarcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:272   
More Information
Causal ncRNA Number:210
Network:
Top Causal ncRNAs:
MALAT1  (Score: 1)
MALAT1  (Score: 1)
HOTAIR  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ELFN1-AS1  (Score: 0.999893)
ZEB2-AS1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
circPPP1R12A  (Score: 0.985791)
CASC9  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:33040438
Disease Name:Colonic Neoplasms
Sample:colon cancer tissues
Dysfunction Pattern:regulation[NF-κB/YY1 axis]
Validated Method:RNA Pull-Down//Western Blot//qRT-PCR//RIP//Luciferase Report Assay//EdU Staining//ChIP
Description: LINC01578 was upregulated in colon cancer, associated with metastasis, advanced clinical stages, poor overall survival, disease-specific survival, and disease-free survival. Collectively, this study demonstrated that LINC01578 promoted colon cancer metastasis via forming a positive feedback loop with NF-κB/YY1 and suggested that LINC01578 represents a potential prognostic biomarker and therapeutic target for colon cancer metastasis.
Causality:Yes
Causal Description:Gain-of-function and loss-of-function assays revealed that LINC01578 enhanced colon cancer cell viability and mobility in vitro and colon cancer liver metastasis in vivo.
Clinical-realted Application: LINC01578 was upregulated in colon cancer, associated with metastasis, advanced clinical stages, poor overall survival, disease-specific survival, and disease-free survival.