Entry Detail

General Information

Database ID: LDA0003815
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDIPTOSP
Full Name:CDIP transferase opposite strand, pseudogene
Category:LncRNA
Species:Homo sapiens
Synonyms:CDIPT-AS1|lnc-CTHCC
Chromosome:16
Strand:+
Coordinate:
Start Site(bp):29863683End Site(bp):29868053
External Links:
Ensembl ID:ENSG00000214725
Ensembl Transcript ID:N/A
Entrez Gene:440356.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Liver Neoplasms  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3571D008113
Disease Name:liver cancerLiver Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A hepatobiliary system cancer that is located_in the liver.Tumors or cancer of the LIVER.
Alias:Ca liver - primary//Resectable malignant neoplasm of Liver//hepatic cancer//hepatic neoplasm//malignant hepato-biliary neoplasm//malignant neoplasm of liver//malignant neoplasm of liver, not specified as primary or secondary//malignant neoplasm of liver, primary//malignant tumor of liver//neoplasm of liver//non-resectable primary hepatic malignant neoplasm//primary liver cancer//primary malignant neoplasm of liver//resectable malignant neoplasm of the liverLiver Neoplasms//Neoplasms, Hepatic//Neoplasms, Liver//Liver Neoplasm//Neoplasm, Liver//Hepatic Neoplasms//Hepatic Neoplasm//Neoplasm, Hepatic//Cancer of Liver//Hepatocellular Cancer//Cancers, Hepatocellular//Hepatocellular Cancers//Hepatic Cancer//Cancer, Hepatic//Cancers, Hepatic//Hepatic Cancers//Liver Cancer//Cancer, Liver//Cancers, Liver//Liver Cancers//Cancer of the Liver//Cancer, Hepatocellular

 

Disease Association Statistics

Total Associated ncRNA Number:162   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CEBPA-DT  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
BCAR4  (Score: 0.985791)
BCAR4  (Score: 0.985791)
SNHG1  (Score: 0.985791)
HULC  (Score: 0.985791)
GAS5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:35122073
Disease Name:Liver Neoplasms
Sample:HCC tissues and cells
Dysfunction Pattern:Interaction(hnRNP K/YAP1 )
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Transfection//Migration Assay//qRT-PCR//FISH//RIP//RNA-seq//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay//Invasion Assay//ChIP
Description:Here, we discovered a conserved CT-lncRNA, named lnc-CTHCC, which was highly expressed in the testes and HCC. Mechanistically, lnc-CTHCC bound to heterogeneous nuclear ribonucleoprotein K (hnRNP K), which was recruited to the YAP1 promoter for its activation. Additionally, the N6-methyladenosine (m6A) modification was mediated by N6-adenosine-methyltransferase 70-kDa subunit (METTL3) and recognized by insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)/IGF2BP3, which maintained lnc-CTHCC stability and increased its expression in HCC.
Causality:Yes
Causal Description:A lnc-CTHCC-knockout (KO) mouse model further confirmed that the global loss of lnc-CTHCC inhibited the occurrence and development of HCC. In vitro and in vivo assays also showed that lnc-CTHCC promoted HCC growth and metastasis.
Clinical-realted Application: