Entry Detail

General Information

Database ID: LDA0003817
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CERNA2
Full Name:competing endogenous lncRNA 2 for microRNA let-7b
Category:LncRNA
Species:Homo sapiens
Synonyms:HOST2|lncRNA-HOST2
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):84167228End Site(bp):84172076
External Links:
Ensembl ID:ENSG00000285972
Ensembl Transcript ID:N/A
Entrez Gene:642934.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30290058
Disease Name:Glioma
Sample:Glioma Tissue,cell lines( U251 and U87)
Dysfunction Pattern:Interaction[let-7b;PBX3 ]
Validated Method:CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:Results showed that HOST2 and PBX3 were highly expressed in glioma tissue whereas let-7b was expressed at much lower levels. The expression of let-7b and PBX3 was detected by RT-qPCR and Western blot analysis after the silencing of lncRNA HOST2. The results showed (Fig. 3E) that the expression of let-7b increased and PBX3 decreased significantly (all P < 0.05) in the si-lncRNA HOST2 groExpression[Expression[up-expression]-expression] compared with the blank groExpression[Expression[up-expression]-expression] and the si-Con groExpression[Expression[up-expression]-expression]. These results suggested that lncRNA HOST2 functioned as a ceRNA and regulated the expression of PBX3 by competitively binding to let-7b.
Causality:Yes
Causal Description:Results showed that the high expression of HOST2 in gliomas inhibits the expression of target gene PBX3 induced by let-7b and promotes the development of gliomas. Our results were consistent with recent reports of some related lncRNA RNAs. For instance, knockExpression[down-expression] of lncRNA FOXD3 antisense RNA 1 inhibited the cell growth, migration, and invasion of malignant glioma cells 25. Another study showed that Expression[down-expression]-regulation of lncRNA CCAT2 inhibited cellular proliferation and invasion in glioma cells 26. However, our investigation was the first to demonstrate that knockExpression[down-expression] of lncRNA HOST2 expression may inhibit the growth, migration, and invasion in glioma cells.
Clinical-realted Application: