Entry Detail

General Information

Database ID: LDA0003826
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDYL
Full Name:chromodomain Y like
Category:LncRNA
Species:Homo sapiens
Synonyms:CDYL1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):4706138End Site(bp):4955544
External Links:
Ensembl ID:ENSG00000153046
Ensembl Transcript ID:N/A
Entrez Gene:9425.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Multiple Myeloma  (Score: 0.731059)
Multiple Myeloma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9538D009101
Disease Name:multiple myelomaMultiple Myeloma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid neoplasm that is located_in the plasma cells in bone marrow.A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Alias:Multiple Myeloma//Multiple Myelomas//Myelomas, Multiple//Myeloma, Multiple//Myeloma, Plasma-Cell//Myeloma, Plasma Cell//Myelomas, Plasma-Cell//Plasma-Cell Myeloma//Plasma-Cell Myelomas//Myelomatosis//Myelomatoses//Plasma Cell Myeloma//Cell Myeloma, Plasma//Cell Myelomas, Plasma//Myelomas, Plasma Cell//Plasma Cell Myelomas//Kahler Disease//Disease, Kahler//Myeloma-Multiple//Myeloma Multiple//Myeloma-Multiples

 

Disease Association Statistics

Total Associated ncRNA Number:180   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
NEAT1  (Score: 1)
CDKN2B-AS1  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
MALAT1  (Score: 0.999893)
ST3GAL6-AS1  (Score: 0.999893)
hsa_circ_0007841  (Score: 0.985791)
lnc-TCF7  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//qPCR//Cell Apoptosis Assay//PCR//IF
Weak Evidence:

 

Reference

[1] PubMed ID:32321304
Disease Name:Multiple Myeloma
Sample:MM cells and plasma
Dysfunction Pattern:interaction[sponges miR-1180]
Validated Method:RNA Pull-Down//Western Blot//qPCR//PCR//Cell Apoptosis Assay//IF
Description:Here, we described an important MM-related circular RNA (circRNA), circ-CDYL. It was remarkably increased in both MM cells and plasma.Circ-CDYL could absorb miR-1180 and alleviated the repression of miR-1180 on YAP, leading to increased YAP expression, ultimately triggering MM uncontrolled growth.
Causality:Yes
Causal Description:Depletion of circ-CDYL evidently stunted MM growth.
Clinical-realted Application: