Entry Detail

General Information

Database ID: LDA0003853
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CERNA2
Full Name:competing endogenous lncRNA 2 for microRNA let-7b
Category:LncRNA
Species:Homo sapiens
Synonyms:HOST2|lncRNA-HOST2
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):84167228End Site(bp):84172076
External Links:
Ensembl ID:ENSG00000285972
Ensembl Transcript ID:N/A
Entrez Gene:642934.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:10
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Triple Negative Breast Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//MTT//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31949664
Disease Name:Stomach Neoplasms
Sample:GC tissues and cell lines
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//MTT
Description:In this study, we found that CERNA2 expression was significantly increased in GC tissues and cell lines compared to adjacent non-cancerous tissues and normal gastric epithelial cells, respectively.
Causality:Yes
Causal Description: Moreover, silencing CERNA2 expression effectively inhibited gastric cancer cell growth and induced cell apoptosis in vitro. Collectively, our results demonstrate that the up-regulation of CERNA2 is associated with malignant status and poor prognosis in patients with GC, and silencing CERNA2 expression inhibits gastric cancer cell growth and promotes cell apoptosis, suggesting CERNA2 could possibly be a promising diagnostic and treatment target for GC.
Clinical-realted Application:High levels of CERNA2 were correlated with poor clinical parameters and an unfavorable prognosis of GC patients.

[2] PubMed ID:30509094
Disease Name:Stomach Neoplasms
Sample:gastric cancer tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:Western Blot//Wound Healing Assay//CCK8//qRT-PCR//Microarray//Transwell Assay
Description:The results revealed that the HOST2 expression in the GC tumor tissues increased significantly compared to adjacent normal tissue (Figure 1B, **p<0.01).
Causality:No
Causal Description:
Clinical-realted Application: