Entry Detail

General Information

Database ID: LDA0003865
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994791End Site(bp):22121097
External Links:
Ensembl ID:ENSG00000240498
Ensembl Transcript ID:N/A
Entrez Gene:100048912.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Glioma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4481D065631
Disease Name:allergic rhinitisRhinitis, Allergic
Category:Disease OntologyMeSH
Type:Respiratory Tract Diseases
Define:A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites.An inflammation of the NASAL MUCOSA triggered by ALLERGENS.
Alias:Non-seasonal allergic rhinitis//Perenial allergic rhinitis//atopic rhinitis//hay fever//pollenosis//seasonal allergic rhinitisRhinitis, Allergic//Allergic Rhinitides//Rhinitides, Allergic//Allergic Rhinitis

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0067835  (Score: 0.731059)
HCP5  (Score: 0.731059)
FR215775  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:35404176
Disease Name:Rhinitis, Allergic
Sample:AR cell model
Dysfunction Pattern:Interaction(miR-16-5p/TLR4 Axis)
Validated Method:qRT-PCR//Luciferase Report Assay//RIP//Western Blot
Description:Moreover, knockdown of ANRIL reversed the effect of AR on autophagy-related protein and tight junction proteins MiR-16-5p was found to be bound with ANRIL and miR-16-5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction. In addition, miR-16-5p directly targeted TLR4. Furthermore, knockdown of ANRIL reversed miR-16-5p and TLR4 expression, autophagy level, and tight junction protein levels in nasal mucosa of AR mice.
Causality:Yes
Causal Description:Moreover, knockdown of ANRIL reversed the effect of AR on autophagy-related protein and tight junction proteins MiR-16-5p was found to be bound with ANRIL and miR-16-5p inhibitor could reverse ANRIL knockdown-induced downregulation of autophagy-related proteins and epithelial barrier dysfunction. In addition, miR-16-5p directly targeted TLR4. Furthermore, knockdown of ANRIL reversed miR-16-5p and TLR4 expression, autophagy level, and tight junction protein levels in nasal mucosa of AR mice.
Clinical-realted Application:

[2] PubMed ID:31096432
Disease Name:Rhinitis, Allergic
Sample:nasal mucosa tissue
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR
Description:LncRNA ANRIL expression was increased in AR patients (3.605 [1.763-4.981]) compared with controls (1.183 [0.438-2.985]),
Causality:No
Causal Description:
Clinical-realted Application: