Entry Detail

General Information

Database ID: LDA0003868
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CDKN2B-AS1
Full Name:CDKN2B antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS
Chromosome:9
Strand:+
Coordinate:
Start Site(bp):21994791End Site(bp):22121097
External Links:
Ensembl ID:ENSG00000240498
Ensembl Transcript ID:N/A
Entrez Gene:100048912.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:96   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Breast Neoplasms  (Score: 1)
Glioma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Ovarian Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Leukemia, Myeloid, Acute  (Score: 0.999893)
Glioma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2876
Disease Name:laryngeal squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A laryngeal carcinoma that has_material_basis_in squamous cells.
Alias:Epidermoid carcinoma of the Larynx//squamous cell carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
CDKN2B-AS1  (Score: 0.985791)
CDKN2B-AS1  (Score: 0.985791)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
hsa_circ_0067934  (Score: 0.731059)
TACR3-AS1  (Score: 0.731059)
LINC01638  (Score: 0.731059)
AC023794.4-201  (Score: 0.731059)
hsa_circ_0006232  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31754305
Disease Name:laryngeal squamous cell carcinoma
Sample:LSCC tissues
Dysfunction Pattern:Interaction[miR-497/CDK6 Pathway]
Validated Method:qRT-PCR//Luciferase Report Assay
Description:The expression of CDKN2B-AS1 was significantly higher in LSCC tissues than in adjacent normal tissues. Mechanically, CDKN2B functions as an oncogenic lncRNA in LSCC via regulating miR-497/CDK6 axis.
Causality:Yes
Causal Description:Moreover, CDKN2B-AS1 knockdown by siRNA significantly inhibited the proliferation, induced cell apoptosis, and suppressed migration and invasion in LSCC cells.
Clinical-realted Application:Higher CDKN2B-AS1 was closely associated with lymph node metastasis and advanced clinical stage.

[2] PubMed ID:31960744
Disease Name:laryngeal squamous cell carcinoma
Sample:LSCC tissues
Dysfunction Pattern:regulation[CDKN2B-AS1/miR-324-5p/ROCK1 axis ]
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay
Description:CDKN2B-AS1 was upregulated in LSCC tissues, and the upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis. The upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis and promoted LSCC cell growth via miR-324-5p/ROCK1 axis.
Causality:Yes
Causal Description: In AMC-HN-8 cells, the knockdown of CDKN2B-AS1 by siRNA inhibited cell viability, blocked cell cycle in G1 phase, and increased the expression levels of cyclin-dependent kinase inhibitor 1A (p21), cleaved caspase3, and cleaved PPoly (ADP-Ribose) polymerase 1.
Clinical-realted Application:CDKN2B-AS1 was upregulated in LSCC tissues, and the upregulation of CDKN2B-AS1 was correlated with overall survival, advanced clinical stage, and lymph node metastasis.