Entry Detail

General Information

Database ID: LDA0003890
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DRAIC
Full Name:downregulated RNA in cancer, inhibitor of cell invasion and migration
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):69561720End Site(bp):69571440
External Links:
Ensembl ID:ENSG00000245750
Ensembl Transcript ID:N/A
Entrez Gene:145837.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Hirschsprung Disease  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down//Luciferase Report Assay//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:31497998
Disease Name:Nasopharyngeal carcinoma
Sample:NPC tissues
Dysfunction Pattern:Regulation[DRAIC-miR-122-SATB1 axis ]
Validated Method:qRT-PCR//Luciferase Report Assay//RNA Pull-Down//RIP
Description:In this study, we found that DRAIC was significantly increased in NPC tissues. In conclusion, these findings revealed the important roles of DRAIC-miR-122-SATB1 axis in NPC and suggested that DRAIC may be a potential therapeutic target for NPC.
Causality:Yes
Causal Description:Functional assays revealed that ectopic expression of DRAIC enhances NPC cell growth, migration and invasion. DRAIC knockdown represses NPC cell growth, migration and invasion.
Clinical-realted Application: