Entry Detail

General Information

Database ID: LDA0003892
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DRAIC
Full Name:downregulated RNA in cancer, inhibitor of cell invasion and migration
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:15
Strand:+
Coordinate:
Start Site(bp):69561720End Site(bp):69571440
External Links:
Ensembl ID:ENSG00000245750
Ensembl Transcript ID:N/A
Entrez Gene:145837.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
Adenocarcinoma of Lung  (Score: 0.731059)
Hirschsprung Disease  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10487D006627
Disease Name:Hirschsprung's diseaseHirschsprung Disease
Category:Disease OntologyMeSH
Type:Digestive System Diseases
Define:A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel.Congenital MEGACOLON resulting from the absence of ganglion cells (aganglionosis) in a distal segment of the LARGE INTESTINE. The aganglionic segment is permanently contracted thus causing dilatation proximal to it. In most cases, the aganglionic segment is within the RECTUM and SIGMOID COLON.
Alias:Hirschsprung disease//aganglionic megacolon//congenital megacolon//macrocolon//pelvirectal achalasia//total intestinal aganglionosisHirschsprung Disease//Disease, Hirschsprung//Megacolon, Congenital//Hirschsprung's Disease//Disease, Hirschsprung's//Hirschsprungs Disease//Megacolon, Aganglionic//Aganglionic Megacolon//Congenital Megacolon//Aganglionosis, Rectosigmoid Colon//Rectosigmoid Colon Aganglionosis//Rectosigmoid Aganglionosis//Aganglionosis, Rectosigmoid//Congenital Intestinal Aganglionosis//Aganglionosis, Colonic//Colonic Aganglionosis//Total Colonic Aganglionosis//Aganglionosis, Total Colonic

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
cir-CCDC66  (Score: 0.731059)
DRAIC  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
RMST  (Score: 0.731059)
circITCH  (Score: 0.731059)
ZFAS1  (Score: 0.731059)
cir-CCDC66  (Score: 0.731059)
DRAIC  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
RMST  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34471485
Disease Name:Hirschsprung Disease
Sample:colon tissue
Dysfunction Pattern:Interaction(miR-34a-5p/ITGA6 signal axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//CCK8//qRT-PCR//Luciferase Report Assay//Transwell Assay
Description:The lncRNA DRAIC was significantly increased in colon tissue from HSCR patients. The RNA pull-down and dual-luciferase reporter assays have proven the competitive relationship between DRAIC and ITGA6 through their association with miR-34a-5p.
Causality:Yes
Causal Description:The overexpression of DRAIC inhibited SH-SY5Y cell and human 293T cell proliferation and migration. Knockdown of DRAIC, however, promoted cell proliferation and migration.
Clinical-realted Application: