Entry Detail

General Information

Database ID: LDA0003896
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DOCK9-DT
Full Name:DOCK9 divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:DOCK9-AS2
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):99086723End Site(bp):99088625
External Links:
Ensembl ID:ENSG00000260992
Ensembl Transcript ID:N/A
Entrez Gene:100861541.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Thyroid Cancer, Papillary  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077273
Disease Name:Thyroid Cancer, Papillary
Category:MeSH
Type:Neoplasms
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

 

Disease Association Statistics

Total Associated ncRNA Number:340   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
BICDL3P  (Score: 0.999358)
BICDL3P  (Score: 0.999358)
hsa_circ_0000644  (Score: 0.985791)
circRAPGEF5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32917852
Disease Name:Thyroid Cancer, Papillary
Sample:exosomes
Dysfunction Pattern:regulation[ Wnt/β-catenin pathway]
Validated Method:Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:Based on the result of differentially expressed lncRNAs in PTC via bioinformatics databases, we discovered that DOCK9-AS2 was upregulated in PTC, and presented elevation in plasma exosomes of PTC patients. In conclusion, PTC-CSCs-derived exosomal lncRNA DOCK9-AS2 activated Wnt/β-catenin pathway to aggravate PTC progression, indicating that DOCK9-AS2 was a potential target for therapies in PTC.
Causality:Yes
Causal Description:Functionally, DOCK9-AS2 knockdown reduced proliferation, migration, invasion, epithelial-to-mesenchymal (EMT) and stemness in PTC cells.
Clinical-realted Application: