Entry Detail

General Information

Database ID: LDA0003907
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DUXAP10
Full Name:double homeobox A pseudogene 9
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01296|LNMAT1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):19062377End Site(bp):19107497
External Links:
Ensembl ID:ENSG00000244306
Ensembl Transcript ID:N/A
Entrez Gene:503638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RIP//IF
Weak Evidence:

 

Reference

[1] PubMed ID:33340249
Disease Name:Glioma
Sample:glioma tissues and cells
Dysfunction Pattern:regulation[HuR/Sox12 axis]
Validated Method:qRT-PCR//RIP//IF
Description:Here, we show that DUXAP10 is overexpressed in glioma tissues and cells. Further rescuing experiments show that the HuR/Sox12 axis is responsible for DUXAP10-mediated effects on glioma cell stemness.
Causality:Yes
Causal Description:Loss of function experiments reveal that DUXAP10 knockdown has little effects on glioma cell viability, but significantly reduces the stemness of glioma cells, which is characterized as the decrease of stemness marker expression, tumor sphere-forming ability, and ALDH activity.
Clinical-realted Application: