Entry Detail

General Information

Database ID: LDA0003908
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DUXAP10
Full Name:double homeobox A pseudogene 9
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01296|LNMAT1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):19062377End Site(bp):19107497
External Links:
Ensembl ID:ENSG00000244306
Ensembl Transcript ID:N/A
Entrez Gene:503638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Transfection//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:29286182
Disease Name:Pancreatic Neoplasms
Sample:PC tissues and cells
Dysfunction Pattern:Interaction( EZH2 and LSD1)
Validated Method:In Vivo Experiment//Transfection//Invasion Assay//Migration Assay//Flow Cytometry//qRT-PCR//RIP//Microarray//Colony Formation Assay//Bioinformatics Analysis
Description:In this study, we found that DUXAP10 was overexpressed in PC tissues compared with normal tissues. Mechanistic studies revealed that DUXAP10 has a crucial role in G2/M arrest. We further showed that DUXAP10 regulated PC cell proliferation through interact with RNA-binding protein EZH2 and LSD1.
Causality:Yes
Causal Description:Bioinformatic analysis showed that cell cycle progression was increased in patients with high DUXAP10 expression. In vitro and in vivo assays of DUXAP10 alterations revealed a complex integrated phenotype affecting cell growth, apoptosis, migration, and invasion.
Clinical-realted Application:DUXAP10 expression was significantly higher in patients with an advanced TNM stage and positive lymph node metastasis.