Entry Detail

General Information

Database ID: LDA0003910
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DUXAP10
Full Name:double homeobox A pseudogene 9
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01296|LNMAT1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):19062377End Site(bp):19107497
External Links:
Ensembl ID:ENSG00000244306
Ensembl Transcript ID:N/A
Entrez Gene:503638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
Melanoma  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1909D008545
Disease Name:melanomaMelanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye.A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
Alias:Naevocarcinoma//malignant melanomaMelanoma//Melanomas//Malignant Melanoma//Malignant Melanomas//Melanoma, Malignant//Melanomas, Malignant

 

Disease Association Statistics

Total Associated ncRNA Number:164   
More Information
Causal ncRNA Number:154
Network:
Top Causal ncRNAs:
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
hsa_circ_0079593  (Score: 0.999893)
NEAT1  (Score: 0.999893)
MEG3  (Score: 0.985791)
MALAT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TUG1  (Score: 0.985791)
TINCR  (Score: 0.985791)
LINC-PINT  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:RIP//Wound Healing Assay//Transwell Assay//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:31334110
Disease Name:Melanoma
Sample:MM tissues and cells
Dysfunction Pattern:Interaction[Suppressing CADM1 ]
Validated Method:RIP//Wound Healing Assay//qRT-PCR//Transwell Assay
Description:Here, we found that LNMAT1 was upregulated in MM tissues and cells, and its expression levels were further enhanced in MM patients with lymph node metastasis and metastatic MM cells.Lastly, rescue assays demonstrated that LNMAT1 promoted cell migration and invasion of MM by suppressing CADM1 expression.
Causality:Yes
Causal Description:Using loss-of-function assays, we found that LNMAT1 promoted cell migration and invasion and lung metastasis in MM in vitro and in vivo.
Clinical-realted Application:Here, we found that LNMAT1 was upregulated in MM tissues and cells, and its expression levels were further enhanced in MM patients with lymph node metastasis and metastatic MM cells.