Entry Detail

General Information

Database ID: LDA0003915
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DSCR8
Full Name:Down syndrome critical region 8
Category:LncRNA
Species:Homo sapiens
Synonyms:C21orf65|CT25.1a|CT25.1b|MMA-1|MMA-1a|MMA-1b|MMA1|MTAG2
Chromosome:21
Strand:+
Coordinate:
Start Site(bp):38121451End Site(bp):38156511
External Links:
Ensembl ID:ENSG00000198054
Ensembl Transcript ID:N/A
Entrez Gene:84677.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2394D010051
Disease Name:ovarian cancerOvarian Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the ovary.Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
Alias:malignant Ovarian tumor//malignant tumour of ovary//ovarian neoplasm//ovary neoplasm//primary ovarian cancer//tumor of the OvaryOvarian Neoplasms//Neoplasm, Ovarian//Ovarian Neoplasm//Ovary Neoplasms//Neoplasm, Ovary//Neoplasms, Ovary//Ovary Neoplasm//Neoplasms, Ovarian//Ovary Cancer//Cancer, Ovary//Cancers, Ovary//Ovary Cancers//Ovarian Cancer//Cancer, Ovarian//Cancers, Ovarian//Ovarian Cancers//Cancer of Ovary//Cancer of the Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:478   
More Information
Causal ncRNA Number:418
Network:
Top Causal ncRNAs:
PVT1  (Score: 1)
ATB  (Score: 1)
GAS5  (Score: 1)
PVT1  (Score: 1)
KCNQ1OT1  (Score: 1)
ATB  (Score: 1)
XIST  (Score: 1)
SNHG3  (Score: 1)
NEAT1  (Score: 1)
KCNQ1OT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32984052
Disease Name:Ovarian Neoplasms
Sample:OC tissues
Dysfunction Pattern:regulation[DSCR8/miR-98-5p/STAT3/HIF-α axis]
Validated Method:Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description:DSCR8 was remarkedly increased in OC tissues and associated with poorer survival of OC patients. The present results suggested a positive feedback loop of lncRNA DSCR8/miR-98-5p/STAT3/HIF-α axis in the progression of OC.
Causality:Yes
Causal Description:Overexpressing DSCR8 promoted cell proliferation, invasion, and EMT but inhibited apoptosis.
Clinical-realted Application:DSCR8 was remarkedly increased in OC tissues and associated with poorer survival of OC patients.