Entry Detail

General Information

Database ID: LDA0003938
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DLX6-AS1
Full Name:DLX6 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:DLX6-AS|DLX6AS|Evf-2|NCRNA00212
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):96968515End Site(bp):97014065
External Links:
Ensembl ID:ENSG00000231764
Ensembl Transcript ID:N/A
Entrez Gene:285987.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:44   
More Information
Causal Disease Number:44
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Neuroblastoma  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
Neuroblastoma  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Osteosarcoma  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077216
Disease Name:Carcinoma, Ovarian Epithelial
Category:MeSH
Type:Neoplasms
Define:A malignant neoplasm that originates in cells on the surface EPITHELIUM of the ovary and is the most common form of ovarian cancer. There are five histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Mutations in BRCA1, OPCML, PRKN, PIK3CA, AKT1, CTNNB1, RRAS2, and CDH1 genes are associated with this cancer.
Alias:Carcinoma, Ovarian Epithelial//Epithelial Carcinoma, Ovarian//Ovarian Epithelial Carcinomas//Epithelial Ovarian Cancer//Ovarian Epithelial Cancer//Cancer, Ovarian Epithelial//Epithelial Cancer, Ovarian//Ovarian Epithelial Cancers//Ovarian Cancer, Epithelial//Cancer, Epithelial Ovarian//Epithelial Ovarian Cancers//Ovarian Epithelial Carcinoma//Epithelial Ovarian Carcinoma//Carcinoma, Epithelial Ovarian//Epithelial Ovarian Carcinomas//Ovarian Carcinoma, Epithelial

 

Disease Association Statistics

Total Associated ncRNA Number:102   
More Information
Causal ncRNA Number:80
Network:
Top Causal ncRNAs:
HIF1A-AS2  (Score: 0.985791)
HIF1A-AS2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circBNC2  (Score: 0.985791)
circN4BP2L2  (Score: 0.985791)
hsa_circ_0072995  (Score: 0.731059)
circATP2B4  (Score: 0.731059)
HOXB-AS3  (Score: 0.731059)
circRHOBTB3  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31081076
Disease Name:Carcinoma, Ovarian Epithelial
Sample:EOC tissues and cells
Dysfunction Pattern:Regulation[Notch signaling pathway]
Validated Method:qRT-PCR//Western Blot
Description:We first verified the increased expression of DLX6-AS1 in EOC patient samples and cell lines.Mechanistic studies revealed that the knockdown of DLX6-AS1 down-regulated Notch1, p21, and Hes1, indicating that the activity of the Notch signaling pathway was inhibited.
Causality:Yes
Causal Description:Functionally, the down-regulation of DLX6-AS1 decreased EOC cells proliferation, migration, invasion and induced cell cycle G1/S phase arrest and cell apoptosis.
Clinical-realted Application: Clinical assays indicated that high DLX6-AS1 was significantly associated with FIGO stage, lymph node metastasis and poor prognosis. Furthermore, multivariate Cox regression analysis confirmed DLX6-AS1 as an independent prognostic factor in EOC patients.